The vinyl sulfone motif as a structural unit for novel drug design and discovery
YC Xiao, FE Chen - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Vinyl sulfones are a special sulfur-containing structural unit that have attracted
considerable attention, owing to their important role in serving as key structural motifs of …
considerable attention, owing to their important role in serving as key structural motifs of …
Cathepsin B: the dawn of tumor therapy
F Liu, T Zhou, S Zhang, Y Li, Y Chen, Z Miao… - European Journal of …, 2024 - Elsevier
Cathepsin B (CTSB) is a key lysosomal protease that plays a crucial role in the development
of cancer. This article elucidates the relationship between CTSB and cancer from the …
of cancer. This article elucidates the relationship between CTSB and cancer from the …
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells
Background Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a
canonical actin capping protein, participates in endosomal trafficking, yet its precise role in …
canonical actin capping protein, participates in endosomal trafficking, yet its precise role in …
ACE2 and TMPRSS2 expression in patients before, during, and after SARS-CoV-2 infection
HBS Grisard, MA Schörner, FH Barazzetti… - Frontiers in Cellular …, 2024 - frontiersin.org
During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and
transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight …
transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight …
Cholesterol and COVID-19—therapeutic opportunities at the host/virus interface during cell entry
T Grewal, MKL Nguyen, C Buechler - Life Science Alliance, 2024 - life-science-alliance.org
The rapid development of vaccines to combat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections has been critical to reduce the severity of COVID-19 …
coronavirus 2 (SARS-CoV-2) infections has been critical to reduce the severity of COVID-19 …
Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L
W Deng, X Hu, X Tian, Y Zhang, W Shang… - Journal of Medicinal …, 2024 - ACS Publications
Cathepsin L (CatL) is a promising antiviral drug target of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) as an important protease for cleaving the SARS-CoV-2 spike …
coronavirus 2 (SARS-CoV-2) as an important protease for cleaving the SARS-CoV-2 spike …
Establishment of replication-competent vesicular stomatitis virus recapitulating SADS-CoV entry
Zoonotic coronaviruses pose a continuous threat to human health, with newly identified bat-
borne viruses like swine acute diarrhea syndrome coronavirus (SADS-CoV) causing high …
borne viruses like swine acute diarrhea syndrome coronavirus (SADS-CoV) causing high …
Structure-based virtual screening methods for the identification of novel phytochemical inhibitors targeting furin protease for the management of COVID-19
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with …
syndrome coronavirus 2 (SARS-CoV-2) virus, is a highly contagious respiratory disease with …
A flexible, image-based, high-throughput platform encompassing in-depth cell profiling to identify broad-spectrum coronavirus antivirals with limited off-target effects
J Doijen, I Heo, K Temmerman, P Vermeulen, A Diels… - Antiviral Research, 2024 - Elsevier
The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) posed a major threat to global health. Although the World Health Organization …
CoV-2) posed a major threat to global health. Although the World Health Organization …
A Narrative Review of the State of the Art of CCR4-Based Therapies in Cutaneous T-Cell Lymphomas: Focus on Mogamulizumab and Future Treatments
C Zengarini, A Guglielmo, M Mussi, G Motta… - Antibodies, 2024 - mdpi.com
The CCR4 receptor is a pivotal target in cutaneous T-cell lymphoma (CTCL) therapy due to
its role in impairing immune responses against malignant T-cells and expression profiles …
its role in impairing immune responses against malignant T-cells and expression profiles …