[HTML][HTML] From Ocean to Medicine: Harnessing Seaweed's Potential for Drug Development

J Cotas, S Lomartire, AMM Gonçalves… - International Journal of …, 2024 - mdpi.com
Seaweed, a miscellaneous group of marine algae, has long been recognized for its rich
nutritional composition and bioactive compounds, being considered nutraceutical …

The impact of carrageenan on pharmascience

A Bhatt, N Nainwal, P Purohit - Current Traditional Medicine, 2024 - ingentaconnect.com
Carrageenan (CG) a sulfated polysaccharide (SP) is produced using a variety of seaweeds
from the Rhodophyceae family. This type of seaweed is available in areas, like the Atlantic …

Delivery of agarose-aided sprays to the posterior nose for mucosa immunization and short-term protection against infectious respiratory diseases

A Seifelnasr, M Talaat, XA Si, J Xi - Current Pharmaceutical …, 2024 - ingentaconnect.com
Aim: The study aimed to deliver sprays to the posterior nose for mucosa immunization or
short-term protection. Background: Respiratory infectious diseases often enter the human …

[HTML][HTML] Why Certain Repurposed Drugs Are Unlikely to Be Effective Antivirals to Treat SARS-CoV-2 Infections

SJ Hurwitz, R De, JC LeCher, JA Downs-Bowen… - Viruses, 2024 - mdpi.com
Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median
effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical …

[HTML][HTML] An Update on the Chemical Constituents and Biological Properties of Selected Species of an Underpinned Genus of Red Algae: Chondrus

SJ Park, A Sharma, HJ Lee - Marine Drugs, 2024 - mdpi.com
Macroalgae, particularly red seaweeds, have attracted significant attention due to their
economic and health benefits. Chondrus, a red algae genus, despite its economic …

[HTML][HTML] SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK

S Bhattacharyya, JK Tobacman - Signal Transduction and Targeted …, 2024 - nature.com
Immunostaining in lungs of patients who died with COVID-19 infection showed increased
intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4 …

[HTML][HTML] Natural products as a source of Coronavirus entry inhibitors

D Szabó, A Crowe, C Mamotte… - Frontiers in Cellular and …, 2024 - frontiersin.org
The COVID-19 pandemic has had a significant and lasting impact on the world. Four years
on, despite the existence of effective vaccines, the continuous emergence of new SARS …

Developing a novel mucociliary clearance boundary condition (MCBC) to simulate micro-scale particle transfers inside the respiratory tract system without generating …

MA Modaresi, E Shirani - Chaos, Solitons & Fractals, 2024 - Elsevier
The respiratory tract system is protected against pathogens and contaminants by the
mucociliary clearance phenomenon. Simulating the effects of mucociliary clearance is an …

NIoBReTH: A novel integrative paradigm of protection against SARS-CoV-2 and other airborne pathogens with fewer socioeconomic constraints

Q Li, Y Ling, G Chen, S Ye - Medical Hypotheses, 2024 - Elsevier
There is an imperative need of an effective prophylactic strategy to contain or even end the
SARS-CoV-2 pandemic, and to protect the human race from further such pandemics. We …

Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to …

Y Liu, J Zhang, W Liu, Y Pan, S Ruan… - Emerging Microbes & …, 2024 - Taylor & Francis
Following the national dynamic zero-COVID strategy adjustment, the utilization of broad-
spectrum nasal neutralizing antibodies may offer an alternative approach to controlling the …