Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Advancements and mechanisms of stem cell-based therapies for spinal cord injury in animals

B Mili, OP Choudhary - International Journal of Surgery, 2024 - journals.lww.com
Spinal cord injury (SCI) is a neurodegenerative disorder of the central nervous system
(CNS) that can lead to permanent loss of sensation and voluntary movement beyond the …

[HTML][HTML] Advances and Challenges in Spinal Cord Injury Treatments

MA Alvi, KM Pedro, AI Quddusi… - Journal of Clinical …, 2024 - mdpi.com
Spinal cord injury (SCI) is a debilitating condition that is associated with long-term physical
and functional disability. Our understanding of the pathogenesis of SCI has evolved …

Cell Transplantation for Repair of the Spinal Cord and Prospects for Generating Region-Specific Exogenic Neuronal Cells

A Roman, A Huntemer-Silveira… - Cell …, 2024 - journals.sagepub.com
Spinal cord injury (SCI) is associated with currently irreversible consequences in several
functional components of the central nervous system. Despite the severity of injury, there …

Microenvironments‐Modulated Biomaterials Enhance Spinal Cord Injury Therapy

Y Li, Q Zhang, Z Liu, C Fu, J Ding - Advanced Functional …, 2024 - Wiley Online Library
Spinal cord injury (SCI) results from various causes, including sports‐related incidents,
degenerative cervical myelopathy, traffic accidents, and falls. SCI typically leads to sensory …

Advances in Novel Biomaterial-Based Strategies for Spinal Cord Injury Treatment

N Zhang, J Hu, W Liu, W Cai, Y Xu, X Wang… - Molecular …, 2024 - ACS Publications
Spinal cord injury (SCI) is a highly disabling neurological disorder. Its pathological process
comprises an initial acute injury phase (primary injury) and a secondary injury phase …

Stepwise combined cell transplantation using mesenchymal stem cells and induced pluripotent stem cell-derived motor neuron progenitor cells in spinal cord injury

JW Kim, J Kim, H Mo, H Han, YA Rim, JH Ju - Stem Cell Research & …, 2024 - Springer
Background Spinal cord injury (SCI) is an intractable neurological disease in which
functions cannot be permanently restored due to nerve damage. Stem cell therapy is a …

Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered …

JW Kim, J Kim, SM Lee, YA Rim, YC Sung… - Stem Cell Research & …, 2024 - Springer
Background Spinal cord injury (SCI) is a disease that causes permanent impairment of
motor, sensory, and autonomic nervous system functions. Stem cell transplantation for …

[HTML][HTML] Transplantation of Predegenerated Peripheral Nerves after Complete Spinal Cord Transection in Rats: Effect of Neural Precursor Cells and Pharmacological …

A Arriero-Cabañero, E García-Vences… - Cells, 2024 - mdpi.com
Following spinal cord injury (SCI), the regenerative capacity of the central nervous system
(CNS) is severely limited by the failure of axonal regeneration. The regeneration of CNS …

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis

Z Wang, J Li, T Xu, B Guo, Z Xie, M Li - Cellular and Molecular …, 2024 - Springer
Cell transplantation is a promising treatment option for spinal cord injury (SCI). However,
there is no consensus on the choice of carrier scaffolds to host the cells. This study aims to …