Tailoring regulatory components for metabolic engineering in cyanobacteria

P Bolay, N Dodge, K Janssen, PE Jensen… - Physiologia …, 2024 - Wiley Online Library
The looming climate crisis has prompted an ever‐growing interest in cyanobacteria due to
their potential as sustainable production platforms for the synthesis of energy carriers and …

A survey of experimental and computational identification of small proteins

J Beals, H Hu, X Li - Briefings in Bioinformatics, 2024 - academic.oup.com
Small proteins (SPs) are typically characterized as eukaryotic proteins shorter than 100
amino acids and prokaryotic proteins shorter than 50 amino acids. Historically, they were …

Ultrashort‐Peptide‐Responsive Gene Switches for Regulation of Therapeutic Protein Expression in Mammalian Cells

J Huang, S Xue, YQ Xie, AP Teixeira… - Advanced …, 2024 - Wiley Online Library
Despite the array of mammalian transgene switches available for regulating therapeutic
protein expression in response to small molecules or physical stimuli, issues remain …

Integrated sequence and -omic features reveal novel small proteome of Mycobacterium tuberculosis

PR Sinha, R Balasubramanian, SR Hegde - Frontiers in Microbiology, 2024 - frontiersin.org
Bioinformatic studies on small proteins are under-represented due to difficulties in
annotation posed by their small size. However, recent discoveries emphasize the functional …

Analyzing domain features of small proteins using a machine‐learning method

SJ Ding, HP Liao, FM Huang, L Chen, W Guo… - …, 2024 - Wiley Online Library
Small proteins (SPs) are a unique group of proteins that play crucial roles in many important
biological processes. Exploring the biological function of SPs is necessary. In this study, the …

Long Intergenic Non-Coding RNAs of Human Chromosome 18: Focus on Cancers

PV Ershov, EO Yablokov, YV Mezentsev, AS Ivanov - Biomedicines, 2024 - mdpi.com
Malignant neoplasms are characterized by high molecular heterogeneity due to multilevel
deregulation of gene expression and cellular functions. It is known that non-coding RNAs …

PSPI: A deep learning approach for prokaryotic small protein identification

M Weston, H Hu, X Li - Frontiers in Genetics, 2024 - frontiersin.org
Small Proteins (SPs) are pivotal in various cellular functions such as immunity, defense, and
communication. Despite their significance, identifying them is still in its infancy. Existing …

[HTML][HTML] Discovery of antimicrobial peptides in the global microbiome with machine learning

CD Santos-Júnior, MDT Torres, Y Duan, ÁR Del Río… - Cell, 2024 - cell.com
Novel antibiotics are urgently needed to combat the antibiotic-resistance crisis. We present a
machine-learning-based approach to predict antimicrobial peptides (AMPs) within the global …