Beyond a Transmission Cable—New Technologies to Reveal the Richness in Axonal Electrophysiology

JC Mateus, MM Sousa, J Burrone… - Journal of …, 2024 - Soc Neuroscience
The axon is a neuronal structure capable of processing, encoding, and transmitting
information. This assessment contrasts with a limiting, but deeply rooted, perspective where …

Molecular and cellular signalling pathways for promoting neural tissue growth-A tissue engineering approach

K Ramasubbu, G Venkatraman, G Ramanathan… - Life Sciences, 2024 - Elsevier
Neural tissue engineering is a sub-field of tissue engineering that develops neural tissue.
Damaged central and peripheral nervous tissue can be fabricated with a suitable scaffold …

A dual-response fluorescent probe for norepinephrine and viscosity and its application in depression research

X Xiong, J Qiu, S Fu, B Gu, C Zhong, L Zhao… - Spectrochimica Acta Part …, 2024 - Elsevier
Depression is a serious mental disease that causes grievous harm to human health and
quality of life. The vesicular exocytosis of noradrenaline (NE), rather than its intrinsic …

Bio‐inspired Two‐dimensional Nanofluidic Ionic Transistor for Neuromorphic Signal Processing

T Mei, W Liu, F Sun, Y Chen, G Xu… - Angewandte Chemie …, 2024 - Wiley Online Library
Voltage‐gated ion channels prevalent in neurons play important roles in generating action
potential and information transmission by responding to transmembrane potential …

Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles

L Trovò, S Kouvaros, J Schwenk… - EMBO …, 2024 - embopress.org
GABAB receptors (GBRs), the G protein-coupled receptors for GABA, regulate synaptic
transmission throughout the brain. A main synaptic function of GBRs is the gating of Cav2. 2 …

CaV2.1 α1 subunit motifs that control presynaptic CaV2.1 subtype abundance are distinct from CaV2.1 preference

J Li, P Veeraraghavan… - The Journal of physiology, 2024 - Wiley Online Library
Presynaptic voltage‐gated Ca2+ channel (CaV) subtype abundance at mammalian
synapses regulates synaptic transmission in health and disease. In the mammalian central …

[HTML][HTML] Targeting cathepsin S promotes activation of OLF1-BDNF/TrkB axis to enhance cognitive function

HW Lee, SJ Chen, KJ Tsai, KS Hsu, YF Chen… - Journal of biomedical …, 2024 - Springer
Abstract Background Cathepsin S (CTSS) is a cysteine protease that played diverse roles in
immunity, tumor metastasis, aging and other pathological alterations. At the cellular level …

Strongly Adhesive, Self-Healing, Hemostatic Hydrogel for the Repair of Traumatic Brain Injury

Z Dong, J Zhao, J Xu, W Deng, P Sun - Biomacromolecules, 2024 - ACS Publications
With wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in
surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons …

[HTML][HTML] Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx

J Brockhaus, I Kahl, M Ahmad, D Repetto, C Reissner… - Cells, 2024 - mdpi.com
Presynaptic Ca2+ influx through voltage-gated Ca2+ channels (VGCCs) is a key signal for
synaptic vesicle release. Synaptic neurexins can partially determine the strength of …

[HTML][HTML] Nano-organization of synaptic calcium signaling

CI McCarthy, ET Kavalali - Biochemical Society Transactions, 2024 - portlandpress.com
Recent studies suggest an exquisite structural nano-organization within single synapses,
where sites of evoked fusion—marked by clustering of synaptic vesicles, active zone …