Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

The worldwide elderly population is on the rise, and aging is a major osteoporosis risk
factor. Senescent cells accumulation can have a detrimental effect the body as we age. The …

Therapy-induced senescent tumor cells have emerged as significant drivers of tumor
recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production …

Skeletal metastasis is common in patients with advanced breast cancer and often caused by
immune evasion of disseminated tumor cells (DTCs). In the skeleton, tumor cells not only …

Osteonecrosis of the femoral head (ONFH) is a type of ischemic osteonecrosis that causes
pain, loss of function, and femoral head collapse. Here, we analyzed samples of femoral …

Chemotherapy is a widely used treatment for a variety of solid and hematological
malignancies. Despite its success in improving the survival rate of cancer patients …

Marrow Adipocyte Senescence in the Pathogenesis of Bone Loss | Current Osteoporosis
Reports Skip to main content SpringerLink Account Menu Find a journal Publish with us Track …

Mastering new and efficient ways to obtain successful drug delivery systems (DDS) with
controlled release became a paramount quest in the scientific community. Increase of …

With the rise in longevity within the population, medicine continues to encounter fresh
hurdles necessitating prompt actions, among which are those associated with hip joint …

Preparative regimens before Hematopoietic Cell Transplantation (HCT) damage the bone
marrow (BM) microenvironment, potentially leading to secondary morbidity and even …