[HTML][HTML] Novel pharmacological targets for GABAergic dysfunction in ADHD

AS Ferranti, DJ Luessen, CM Niswender - Neuropharmacology, 2024 - Elsevier
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopment disorder that affects
approximately 5% of the population. The disorder is characterized by impulsivity …

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

HH Parent, CM Niswender - Molecular Pharmacology, 2024 - ASPET
Metabotropic glutamate receptor 7 (mGlu7) is the most highly conserved and abundantly
expressed mGlu receptor in the human brain. The presynaptic localization of mGlu7 …

Simultaneous de novo calling and phasing of genetic variants at chromosome-scale using NanoStrand-seq

X Bai, Z Chen, K Chen, Z Wu, R Wang, J Liu, L Chang… - Cell Discovery, 2024 - nature.com
The successful accomplishment of the first telomere-to-telomere human genome assembly,
T2T-CHM13, marked a milestone in achieving completeness of the human reference …

Cortico-striatal differences in the epigenome in attention-deficit/hyperactivity disorder

GG Shastri, G Sudre, K Ahn, B Jung… - Translational …, 2024 - nature.com
While epigenetic modifications have been implicated in ADHD through studies of peripheral
tissue, to date there has been no examination of the epigenome of the brain in the disorder …

[HTML][HTML] GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: systematic review of GRM7 deficient patients

M Zaki-Dizaji, MF Abazari, H Razzaghi… - Brain, Behavior, & …, 2024 - Elsevier
The metabotropic glutamate receptor 7 (mGluR7) is a presynaptic G-protein-coupled
glutamate receptor that modulates neurotransmitter release and synaptic plasticity at …

The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

M Wang, Y Gu, Q Li, B Feng, X Lv, H Zhang, Q Kong… - Genes & …, 2024 - Elsevier
Epilepsy, one of the most common neurological disorders, is characterized by spontaneous
recurrent seizures. Temporal lobe epilepsy (TLE) is one of the most common medically …

A protective role of low polygenic risk score in healthy individuals carrying attention-deficit/hyperactivity disorder–associated copy number variations

X Chang, H Qu, Y Liu, J Glessner, H Hakonarson - Biological Psychiatry, 2024 - Elsevier
Background Previous studies have implicated both rare copy number variations (CNVs) and
common variants in liability for attention-deficit/hyperactivity disorder (ADHD). However, how …

[HTML][HTML] New Advances in Attention-Deficit/Hyperactivity Disorder-like Dogs

Á González-Martínez, S Muñiz de Miguel, FJ Diéguez - Animals, 2024 - mdpi.com
Simple Summary Similar to humans, dogs could suffer a syndrome similar to Attention-
Deficit/Hyperactivity Disorder (ADHD). Several studies suggest that dogs can serve as a …

Association between genetic variants of GRM7 (rs1396409 and rs9883258) and treatment outcomes in Schizophrenic Egyptian patients

AA Alrefai, AN Ramadan, MM Omar… - … Nucleotides & Nucleic …, 2024 - Taylor & Francis
Abstract Background and Aim This study evaluated the association between rs1396409 and
rs9883258 and the risk of schizophrenia (SCZ) and treatment outcomes in Egyptian patients …

Current Perspectives on Attention-deficit Hyperactivity Disorder

S Shafiullah, S Dhaneshwar - Current Molecular Medicine, 2024 - ingentaconnect.com
Attention-deficit hyperactivity disorder (ADHD) is a neurobiological and neurodevelopmental
disorder with an idiosyncratic genetic base. ADHD presents various characteristics, such as …