ULK/Atg1: phasing in and out of autophagy
Autophagy–a highly regulated intracellular degradation process–is pivotal in maintaining
cellular homeostasis. Liquid–liquid phase separation (LLPS) is a fundamental mechanism …
cellular homeostasis. Liquid–liquid phase separation (LLPS) is a fundamental mechanism …
Synthetic activators of autophagy
EA Guseva, JA Pavlova, OA Dontsova… - Biochemistry (Moscow …, 2024 - Springer
Autophagy is a central process for degradation of intracellular components that do not
operate correctly. Molecular mechanisms underlying this process are extremely difficult to …
operate correctly. Molecular mechanisms underlying this process are extremely difficult to …
[HTML][HTML] SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3
Z Wang, C Li, Z Zhang, S Lu, X Wang, Q Liang, X Zhu… - Redox Biology, 2024 - Elsevier
Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid
peroxidation, and could be promoted by activating transcription factor 3 (ATF3). SIRT1 is an …
peroxidation, and could be promoted by activating transcription factor 3 (ATF3). SIRT1 is an …
Upregulated pexophagy limits the capacity of selective autophagy
K Germain, RWL So, LF DiGiovanni, JC Watts… - Nature …, 2024 - nature.com
Selective autophagy is an essential process to maintain cellular homeostasis through the
constant recycling of damaged or superfluous components. Over a dozen selective …
constant recycling of damaged or superfluous components. Over a dozen selective …
Functionalization of seawater reverse osmosis membrane with quorum sensing inhibitor to regulate microbial community and mitigate membrane biofouling
Membrane biofouling is a challenge to be solved for the stable operation of the seawater
reverse osmosis (SWRO) membrane. This study explored the regulation mechanism of …
reverse osmosis (SWRO) membrane. This study explored the regulation mechanism of …
The mechanism of UNC-51-like kinase 1 and the applications of small molecule modulators in cancer treatment
D Sun, Z Zhang, X Yu, H Li, X Wang, L Chen - European Journal of …, 2024 - Elsevier
Autophagy is a process of self-renewal in cells, which not only provides the necessary
nutrients for cells, but also clears necrotic organelles. Autophagy disorders are closely …
nutrients for cells, but also clears necrotic organelles. Autophagy disorders are closely …
[HTML][HTML] IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress
C Xu, Y Song, W Liu, R Liu, Q Bai, L Li, C Wang, G Yan - Redox Biology, 2024 - Elsevier
During asthma, there is an intensification of pulmonary epithelial inflammation,
mitochondrial oxidative stress, and Golgi apparatus fragmentation. However, the underlying …
mitochondrial oxidative stress, and Golgi apparatus fragmentation. However, the underlying …
Enhanced VEGF secretion and blood–brain barrier disruption: Radiation‐mediated inhibition of astrocyte autophagy via PI3K‐AKT pathway activation
S Zhang, M Li, Y Qiu, J Wu, X Xu, Q Ma, Z Zheng, G Lu… - Glia, 2024 - Wiley Online Library
Radiation‐induced damage to the blood–brain barrier (BBB) is the recognized pathological
basis of radiation‐induced brain injury (RBI), a side effect of head and neck cancer …
basis of radiation‐induced brain injury (RBI), a side effect of head and neck cancer …
Targeting autophagy drug discovery: Targets, indications and development trends
M Jiang, W Wu, Z Xiong, X Yu, Z Ye, Z Wu - European Journal of Medicinal …, 2024 - Elsevier
Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …
implicated in the etiology of many diseases. Drugs development targeting autophagy began …