PURPOSE Patients with Down syndrome (DS) and B-ALL experience increased rates of
relapse, toxicity, and death. We report results for patients with DS B-ALL enrolled on …

IKZF1 encodes the transcription factor IKAROS, a zinc finger DNA-binding protein with a key
role in lymphoid lineage development. IKAROS plays a critical role in the development of …

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and
adolescents and in recent decades, the survival rates have risen to> 90% in children largely …

Acute lymphoblastic leukemia (ALL) arises from the uncontrolled proliferation of B-cell
precursors (BCP-ALL) or T cells (T-ALL). Current treatment protocols obtain high cure rates …

Abstract Background Philadelphia chromosome (Ph)–like B‐acute lymphoblastic leukemia
(B‐ALL) is a clinically significant, high‐risk genetic subtype of B‐ALL cases. There are few …

The Ikaros zinc finger factor 1 is a transcription factor with a well-known role in B-and T-cell
development. The deletions of IKZF1 have an established significance in acute …

The association between cytokine receptor-like factor 2 (CRLF2) and clinical outcomes in
acute lymphoblastic leukemia (ALL) has been a topic of ongoing debate, with divergent …

The presence of IKZF1 deletions has been associated with an increased relapse rate in B-
cell precursor acute lymphoblastic leukaemia (BCP-ALL). There is a particular subset of …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) represents a
high-risk B-lineage ALL subtype characterized by adverse clinical features and poor relapse …

ABSTRACT Philadelphia-like (Ph-like) or BCR:: ABL1-like acute lymphoblastic leukemia
(ALL) is a common high-risk subtype of B-cell precursor ALL (B-ALL) characterized by a …