Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …

abstract Obesity is one of the factors associated with the severity of asthma. Obesity is
associated with aggravation of the pathophysiology of asthma, including exacerbations …

IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production
is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its …

Myocardial ischemia-reperfusion injury (MIRI) is a complex process that occurs when blood
flow is restored after myocardium infarction (MI) with exacerbated tissue damage …

Increased eosinophil counts are associated with cardiovascular disease and may be an
independent predictor of major cardiovascular events. However, the causality and …

Objective Genetic relationships between blood eosinophil count (BEC), asthma
susceptibility, and severity are unclear. We sought to identify the genetic difference between …

Neutrophil-lymphocyte (NLR), platelet-lymphocyte (PLR), eosinophil-lymphocyte (ELR), and
monocyte-lymphocyte (MLR) ratios are systemic inflammatory markers related to myocardial …

Background and Aims Elevated eosinophils typically indicate hypersensitive inflammation;
however, their involvement in cardiovascular events remains incompletely understood. We …

Background Lactotransferrin (LTF) has an immunomodulatory function and its expression
levels are associated with asthma susceptibility. Objectives We sought to investigate LTF …

In this issue of Blood, Dou et al 1 reveal a decisive role for hematopoietic lymphocyte
adapter protein (LNK) deficiency in promoting eosinophilia, systemic eosinophil activation …