Modifying Dietary Sodium and Potassium Intake: An End to the'Salt Wars'?
R Little, DH Ellison - Hypertension, 2024 - Am Heart Assoc
Excessive salt intake raises blood pressure, but the implications of this observation for
human health have remained contentious. It has also been recognized for many years that …
human health have remained contentious. It has also been recognized for many years that …
Mitochondrial Dysfunction in Kidney Tubulopathies
CA Hoogstraten, JG Hoenderop… - Annual Review of …, 2024 - annualreviews.org
Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel
energy-demanding water and solute reabsorption processes along the nephron. Moreover …
energy-demanding water and solute reabsorption processes along the nephron. Moreover …
Dysregulation of the WNK4-SPAK/OSR1 pathway has a minor effect on baseline NKCC2 phosphorylation
Y Maeoka, LT Nguyen, A Sharma… - American Journal …, 2024 - journals.physiology.org
The with-no-lysine kinase 4 (WNK4)-sterile 20/SPS-1-related proline/alanine-rich kinase
(SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway mediates activating …
(SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway mediates activating …
Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC
MZ Ferdaus, RB Koumangoye, PA Welling… - Hypertension, 2024 - Am Heart Assoc
BACKGROUND: Potassium regulates the WNK (with no lysine kinase)-SPAK (STE20/SPS1-
related proline/alanine-rich kinase) signaling axis, which in turn controls the phosphorylation …
related proline/alanine-rich kinase) signaling axis, which in turn controls the phosphorylation …
Renal Hypokalemia: An Endocrine Perspective
SA Culver, N Suleman, V Kavuru… - The Journal of Clinical …, 2024 - academic.oup.com
The majority of disorders that cause renal potassium wasting present with abnormalities in
adrenal hormone secretion. While these findings frequently lead patients to seek endocrine …
adrenal hormone secretion. While these findings frequently lead patients to seek endocrine …
Arginine vasopressin regulates the renal Na+-Cl– and Na+-K+-Cl– cotransporters through with-no-lysine kinase 4 and inhibitor 1 phosphorylation
H Carbajal-Contreras… - American Journal …, 2024 - journals.physiology.org
Vasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part
through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway …
through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway …
The first compound heterozygous mutations in SLC12A3 and PDX1 genes: a unique presentation of Gitelman syndrome with distinct insulin resistance and familial …
Y Yin, L Li, S Yu, Y Xin, L Zhu, X Hu, K Chen… - Frontiers in …, 2024 - frontiersin.org
Background Gitelman Syndrome (GS) patients frequently exhibit disrupted glucose
metabolism, attributed to hypokalemia, hypomagnesemia and heightened aldosterone. This …
metabolism, attributed to hypokalemia, hypomagnesemia and heightened aldosterone. This …
Modifying Dietary Sodium and Potassium Intake: An End to the'Salt Wars'?
R Little, DH Ellison - Hypertension, 2024 - ingentaconnect.com
Excessive salt intake raises blood pressure, but the implications of this observation for
human health have remained contentious. It has also been recognized for many years that …
human health have remained contentious. It has also been recognized for many years that …
Role of calcineurin in regulating renal potassium (K+) excretion: Mechanisms of calcineurin inhibitor‐induced hyperkalemia
Calcineurin, protein phosphatase 2B (PP2B) or protein phosphatase 3 (PP3), is a calcium‐
dependent serine/threonine protein phosphatase. Calcineurin is widely expressed in the …
dependent serine/threonine protein phosphatase. Calcineurin is widely expressed in the …
Effects of thiazides and new findings on kidney stones and dysglycemic side effects
M Bargagli, MA Anderegg, DG Fuster - Acta Physiologica, 2024 - Wiley Online Library
Thiazide and thiazide‐like diuretics (thiazides) belong to the most frequently prescribed
drugs worldwide. By virtue of their natriuretic and vasodilating properties, thiazides …
drugs worldwide. By virtue of their natriuretic and vasodilating properties, thiazides …