Physiologic disruption and metabolic reprogramming in infection and sepsis
K Willmann, LF Moita - Cell Metabolism, 2024 - cell.com
Effective responses against severe systemic infection require coordination between two
complementary defense strategies that minimize the negative impact of infection on the host …
complementary defense strategies that minimize the negative impact of infection on the host …
Revolution in sepsis: a symptoms-based to a systems-based approach?
Severe infection and sepsis are medical emergencies. High morbidity and mortality are
linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and …
linked to CNS dysfunction, excessive inflammation, immune compromise, coagulopathy and …
Alterations in leukocyte DNA methylome are associated to immunosuppression in severe clinical phenotypes of septic patients
J Beltrán-García, G Casabó-Vallés… - Frontiers in …, 2024 - frontiersin.org
Introduction Sepsis patients experience a complex interplay of host pro-and anti-
inflammatory processes which compromise the clinical outcome. Despite considering the …
inflammatory processes which compromise the clinical outcome. Despite considering the …
Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities
R Silva-Gomes, I Caldeira, R Fernandes, C Cunha… - 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
individuals worldwide and resulting in more than 3 million deaths annually. Despite …
Pattern-Recognition Receptors and Immunometabolic Reprogramming: What We Know and What to Explore
V Kumar, JH Stewart IV - Journal of Innate Immunity, 2024 - karger.com
Background: Evolutionarily, immune response is a complex mechanism that protects the
host from internal and external threats. Pattern-recognition receptors (PRRs) recognize …
host from internal and external threats. Pattern-recognition receptors (PRRs) recognize …
miR-186-5p improves alveolar epithelial barrier function by targeting the wnt5a/β-catenin signaling pathway in sepsis-acute lung injury
M Li, J Yang, Y Wu, X Ma - International Immunopharmacology, 2024 - Elsevier
Background Alveolar epithelial barrier dysfunction is one of the pathological features of
sepsis-acute lung injury (ALI). However, the molecular mechanisms that regulate the …
sepsis-acute lung injury (ALI). However, the molecular mechanisms that regulate the …
Investigation of shared molecular mechanisms underlying sepsis and heart failure via integrated analysis of multiple microarray data
D Chen, Y Song, H Zhang, Y Ye - 2024 - researchsquare.com
Objective: This study aimed to mine shared genes and related molecular mechanisms of
sepsis and heart failure (HF). Methods: Differentially expressed genes (DEGs) in sepsis and …
sepsis and heart failure (HF). Methods: Differentially expressed genes (DEGs) in sepsis and …