Pioneer transcription factors are proteins with a dual function. First, they regulate
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …

Epigenetic modifications of histone N-terminal tails play a critical role in regulating the
chromatin structure and biological processes such as transcription and DNA repair. One of …

The basic packaging unit of chromatin is the nucleosome, which consists of a 145-147 base
pair DNA wrapped around the histone. The interplay between DNA sequence and …

Chromatinized DNA is targeted by proteins and small molecules to regulate chromatin
function. For example, anthracycline cancer drugs evict nucleosomes in a mechanism that is …

Guanine radical cations are precursors to oxidatively-induced DNA lesions and the
determination of oxidative DNA hot spots beyond oligonucleotides remains a current …

During various DNA-centered processes in the cell nucleus, the minimal structural units of
chromatin organization, nucleosomes, are often transiently converted to hexasomes and …

Nucleosomes are the building blocks of eukaryotic genomes and thus fundamental to to all
genetic processes. Any protein or drug that binds DNA must either cooperate or compete …

DNA damage caused by alkylation and oxidation is harmful to cells, potentially leading to
cell death or cancer. Alkylating drugs and radiotherapy exploit this cytotoxicity to kill tumor …