The brain is a complex organ, fundamentally changing across the day to perform basic
functions like sleep, thought, and regulating whole-body physiology. This requires a …

Mammalian physiology and cellular function are subject to significant oscillations over the
course of every 24-hour day. It is likely that these daily rhythms will affect function as well as …

Circadian rhythms are endogenous biological cycles that regulate physiology and behavior
and are set to precisely 24-h by light exposure. Light at night (LAN) dysregulates physiology …

The circadian clock system orchestrates daily behavioral and physiological rhythms,
facilitating adaptation to environmental and internal oscillations. Disruptions in circadian …

Background Depression is defined by a persistent low mood and disruptions in sleep
patterns, with the WHO forecasting that major depression will rank as the third most …

Stroke, a debilitating condition often leading to long-term disability, poses a substantial
global concern and formidable challenge. The increasing incidence of stroke has drawn the …

Microglia sense the changes in their environment. How microglia actively translate these
changes into suitable cues to adapt brain physiology is unknown. We reveal an activity …

Tauopathies, a group of neurodegenerative diseases that includes Alzheimer's disease,
commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The …

Microglia, a vital homeostasis-keeper of the central nervous system, perform critical
functions such as synaptic pruning, clearance of cellular debris, and participation in …

Circadian rhythms are involved in the regulation of many aspects of the body, including cell
function, physical activity and disease. Circadian disturbance often predates the typical …