Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
Context-specific functions of chromatin remodellers in development and disease
S Gourisankar, A Krokhotin, W Wenderski… - Nature Reviews …, 2024 - nature.com
Chromatin remodellers were once thought to be highly redundant and nonspecific in their
actions. However, recent human genetic studies demonstrate remarkable biological …
actions. However, recent human genetic studies demonstrate remarkable biological …
[HTML][HTML] The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes
S Brahma, S Henikoff - Nature genetics, 2024 - nature.com
Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …
Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility
S Ishii, T Kakizuka, SJ Park, A Tagawa, C Sanbo… - Nature …, 2024 - nature.com
Chromatin accessibility is a hallmark of active regulatory regions and is functionally linked to
transcriptional networks and cell identity. However, the molecular mechanisms and networks …
transcriptional networks and cell identity. However, the molecular mechanisms and networks …
[HTML][HTML] Epigenetic pioneering by SWI/SNF family remodelers
In eukaryotic genomes, transcriptional machinery and nucleosomes compete for binding to
DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate …
DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate …
RNA polymerase II promotes the organization of chromatin following DNA replication
S Bandau, V Alvarez, H Jiang, S Graff… - EMBO …, 2024 - embopress.org
Understanding how chromatin organisation is duplicated on the two daughter strands is a
central question in epigenetics. In mammals, following the passage of the replisome …
central question in epigenetics. In mammals, following the passage of the replisome …
[HTML][HTML] Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF
K Cermakova, L Tao, M Dejmek, M Sala… - Nucleic acids …, 2024 - academic.oup.com
Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of
DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF …
DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF …
Alpha‐synuclein promotes PRMT5‐mediated H4R3me2s histone methylation by interacting with the BAF complex
T Nakamura, N Sugeno, T Hasegawa… - The FEBS …, 2024 - Wiley Online Library
α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …
[HTML][HTML] SWI/SNF-dependent genes are defined by their chromatin landscape
L Basurto-Cayuela, JA Guerrero-Martínez… - Cell Reports, 2024 - cell.com
SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …
[HTML][HTML] Acute depletion of BRG1 reveals its primary function as an activator of transcription
The mammalian SWI/SNF-like BAF complexes play critical roles during animal development
and pathological conditions. Previous gene deletion studies and characterization of human …
and pathological conditions. Previous gene deletion studies and characterization of human …