Synthesis of Novel Hydrazide–Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II

R Çakmak, E Başaran, K Sahin, M Şentürk… - ACS …, 2024 - ACS Publications
The abnormal levels of the human carbonic anhydrase isoenzymes I and II (hCA I and II)
and cholinesterase enzymes, namely, acetylcholinesterase (AChE) and …

Investigation of Newly Synthesized Fluorinated Isatin-Hydrazones by In Vitro Antiproliferative Activity, Molecular Docking, ADME Analysis, and e-Pharmacophore …

E Başaran, S Köprü, S Akkoç… - ACS Omega, 2024 - ACS Publications
In this study, we investigated the in vitro antiproliferative activities and performed
computational studies of newly synthesized fluorinated isatin-hydrazones. The chemical …

Therapeutic potential of the linalool against cadmium-induced testicular tissue damage

T Yalçın, S Kaya - Journal of Trace Elements in Medicine and Biology, 2024 - Elsevier
Cadmium (Cd) is a heavy metal that has harmful effects and is one of the contaminants
found in the environment. Cd exposure causes important pathophysiological processes …

Synthesis, crystal structures, CT-DNA/BSA binding modes and antibacterial activities of Zn (II) and Cr (III) with an acylhydrazone ligand

JY Gao, N Zhang, DS Huang, XR Liu, ZW Yang… - Polyhedron, 2024 - Elsevier
Two salicylaldehyde-4-hydroxy phenylacetyl acylhydrazone transition metal complexes ZnL
2· H 2 O (I) and [CrL 2] NO 3· EtOH (II) were synthesized by C 15 H 14 N 2 O 3 (HL) with Zn …

Synthesis of Novel N-Acylhydrazones Derived from 3,5-Dinitrobenzohydrazide and Evaluation of Their Anticholinesterase and Antioxidant Activities

R Çakmak, E Çınar, E Başaran, G Tuneğ, S İzgi… - Russian Journal of …, 2024 - Springer
Objective: In this study, it was aimed to determine the antioxidant activities and enzyme
inhibition properties of newly synthesized N-acylhydrazone compounds (IIIa–IIIp) bearing an …

Potential therapeutic effect of Thymoquinone on Cisplatin-induced hepatotoxicity in rats

S Kaya, T Yalçın - 2024 - acikerisim.selcuk.edu.tr
Öz Amaç: Antineoplastik bir ajan olan Sisplatin (CIS), hepatotoksisite gibi ciddi yan etkiler
gösterir. Timokinon (ThQ), anti-inflamatuar, anti-tümöral gibi birçok faydalı etkiye sahip güçlü …