Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Glioblastoma (GBM) is one of the most lethal central nervous systems (CNS) tumours in
adults. As supplements to standard of care (SOC), various immunotherapies improve the …

Glioblastoma is the most lethal primary brain tumor with glioblastoma stem cells (GSCs) atop
a cellular hierarchy. GSCs often reside in a perivascular niche, where they receive …

Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and
efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in …

A glioblastoma (GBM) is one of the most aggressive, infiltrative, and treatment-resistant
malignancies of the central nervous system (CNS). The current standard of care for GBMs …

Ferroptosis has emerged as a promising therapeutic approach for glioma. However, its
efficacy is often compromised by the activated GPX4-reduced glutathione (GSH) system and …

Macrophages are the main component of the tumor microenvironment, which are
differentiated from monocytes in the blood and play an important role in cancer …

Background This study focused on minimizing the costs and toxic effects associated with
unnecessary chemotherapy. We sought to optimize the adjuvant therapy strategy, choosing …

Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on
histological features. Recent molecular profiling studies have reshaped the World Health …

Glioblastoma multiforme (GBM) is the most common type of glioma, with a median survival of
14.6 months post-diagnosis. Understanding the molecular profile of such tumors allowed the …