Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

RAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the
signaling cascade that controls cellular proliferation, differentiation, and survival in response …

There is a continuing debate about the proportion of cancer patients that benefit from
precision oncology, attributable in part to conflicting views as to which molecular alterations …

Head and neck squamous cell carcinomas (HNSCCs) are the most devastating diseases in
India and southeast Asia. It is a preventable and curable disease if detected early. Tobacco …

Chromatin remodellers were once thought to be highly redundant and nonspecific in their
actions. However, recent human genetic studies demonstrate remarkable biological …

As a widely considerable target in chemical biology and pharmacological research, rat
sarcoma (RAS) gene mutations play a critical driving factor in several fatal cancers. Despite …

Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays
a pivotal role in organ size control and tumor suppression by inhibiting proliferation and …

In this study, we explore the dynamic process of colorectal cancer progression, emphasizing
the evolution toward a more metastatic phenotype. The term" evolution" as used in this study …

Schwann cell tumors are the most common cancers of the peripheral nervous system and
can arise in patients with neurofibromatosis type-1 (NF-1) or neurofibromatosis type-2 (NF …

The Ras family genes are proto-oncogenes that are highly conserved from Drosophila to
humans. In Drosophila, Ras V12 is a constitutively activated form of the Ras oncoprotein …