Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

Arming human cells with synthetic gene circuits enables to expand their capacity to execute
superior sensing and response actions, offering tremendous potential for innovative cellular …

Proteases function as pivotal molecular switches, initiating numerous biological events.
Notably, potyviral protease, derived from plant viruses, has emerged as a trusted proteolytic …

Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …

Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and
solid cancers. Despite the transformative impact of immunotherapy on cancer treatment …

Natural cell death pathways such as apoptosis and pyroptosis play dual roles: they eliminate
harmful cells and modulate the immune system by dampening or stimulating inflammation …

Cell-cell interactions are central to development, but exploring how a change in any given
cell relates to changes in the neighbour of that cell can be technically challenging. Here, we …

Inducible protein switches are used throughout the biosciences to allow on-demand control
of proteins in response to chemical or optical inputs. However, these inducers either cannot …

Synthetic receptors enable bioengineers to build cell-based therapies that perform
therapeutic functions in a targeted or conditional fashion to enhance specificity and efficacy …