[HTML][HTML] How can we escape the ESKAPEs: Antimicrobial resistance mechanisms and what lies ahead?
JB Kelly, AC Nolan, MS Zeden - PLoS pathogens, 2024 - journals.plos.org
The ESKAPE pathogens are a group of 6 nosocomial pathogens: Enterococcus faecium,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
[HTML][HTML] Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection
The host environment is of critical importance for antibiotic efficacy. By impacting bacterial
machineries, stresses encountered by pathogens during infection promote the formation of …
machineries, stresses encountered by pathogens during infection promote the formation of …
Susceptible bacteria can survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance
M Rodrigues, P Sabaeifard, MS Yildiz, A Lyon… - Cell Host & Microbe, 2024 - cell.com
Antibiotic resistance and evasion are incompletely understood and complicated by the fact
that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in …
that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in …
[HTML][HTML] Fungicide-tolerant persister formation during cryptococcal pulmonary infection
W Ke, Y Xie, Y Chen, H Ding, L Ye, H Qiu, H Li… - Cell Host & Microbe, 2024 - cell.com
Bacterial persisters, a subpopulation of genetically susceptible cells that are normally
dormant and tolerant to bactericides, have been studied extensively because of their clinical …
dormant and tolerant to bactericides, have been studied extensively because of their clinical …
Freeze‐Thaw Microfluidic System Produces “Themis” Nanocomplex for Cleaning Persisters‐Infected Macrophages and Enhancing Uninfected Macrophages
M Su, M Yin, Y Zhou, S Xiao, J Yi, R Tang - Advanced Materials, 2024 - Wiley Online Library
Macrophages are the primary effectors against potential pathogen infections. They can be
“parasitized” by intracellular bacteria, serving as “accomplices”, protecting intracellular …
“parasitized” by intracellular bacteria, serving as “accomplices”, protecting intracellular …
Emergent antibiotic persistence in a spatially structured synthetic microbial mutualism
Antibiotic persistence (heterotolerance) allows a subpopulation of bacteria to survive
antibiotic-induced killing and contributes to the evolution of antibiotic resistance. Although …
antibiotic-induced killing and contributes to the evolution of antibiotic resistance. Although …
Metabolic flux regulates growth transitions and antibiotic tolerance in uropathogenic Escherichia coli
JJ Morrison, EK Madden, DA Banas… - Journal of …, 2024 - Am Soc Microbiol
Reducing growth and limiting metabolism are strategies that allow bacteria to survive
exposure to environmental stress and antibiotics. During infection, uropathogenic …
exposure to environmental stress and antibiotics. During infection, uropathogenic …
Advancing Biological Applications Through Microfluidic-Based Tool Development
KM Rahman - 2024 - openprairie.sdstate.edu
This research undertook an interdisciplinary approach, integrating bioengineering,
microbiology, molecular biology, and systems biology to investigate bacterial dynamics …
microbiology, molecular biology, and systems biology to investigate bacterial dynamics …