In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …

Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …

Adding a cationic helper lipid to a lipid nanoparticle (LNP) can increase lung delivery and
decrease liver delivery. However, it remains unclear whether charge-dependent tropism is …

Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …

Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable clinical success in
the treatment of hematological malignancies. However, producing these bespoke cancer …

Macrophages are integral components of the innate immune system, playing a dual role in
host defense during infection and pathophysiological states. Macrophages contribute to …

Abstract Poly (ethylene glycol)(PEG)–lipids are used in Food‐and‐Drug‐Administration‐
approved lipid nanoparticle (LNP)–RNA drugs, which are safe and effective. However, it is …

Imaging flow cytometry (IFC) combines flow cytometry and fluorescence microscopy to
enable high-throughput, multiparametric single-cell analysis with rich spatial details …

In recent years, messenger RNA (mRNA) vaccines have exhibited great potential to replace
conventional vaccines owing to their low risk of insertional mutagenesis, safety and efficacy …

Messenger RNA (mRNA) cancer vaccines are a new class of immunotherapies that can
activate the immune system to recognize and destroy cancer cells. However, their …