Dynamic interactions between organelles are responsible for a variety of intercellular
functions, and the endoplasmic reticulum (ER)–mitochondrial axis is recognized as a …

Intracellular Ca 2+ signals play a vital role in a broad range of cell biological and
physiological processes in all eukaryotic cell types. Dysregulation of Ca 2+ signaling has …

Lysosomes and the endoplasmic reticulum (ER) are Ca 2+ stores mobilized by the second
messengers NAADP and IP 3, respectively. Here, we establish Ca 2+ signals between the …

Inositol 1, 4, 5-trisphosphate (IP3) receptor type 1 (ITPR1), 2 (ITPR2), and 3 (ITPR3) encode
the IP3 receptor (IP3R), a key player in intracellular calcium release. In four unrelated …

Background The ITPR1 gene encodes the inositol 1, 4, 5‐trisphosphate (IP3) receptor type 1
(IP3R1), a critical player in cerebellar intracellular calcium signaling. Pathogenic missense …

Abstract Aim Inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are intracellular Ca2+‐release
channels with crucial roles in cell function. Current IP3R inhibitors suffer from off‐target …

The spatial organization of inositol 1, 4, 5-trisphosphate (IP 3)-evoked Ca 2+ signals
underlies their versatility. Low stimulus intensities evoke Ca 2+ puffs, localized Ca 2+ …

Cell fate is tightly controlled by a continuous balance between cell survival and cell death
inducing mechanisms. B-cell lymphoma 2 (Bcl-2)-family members, composed of effectors …

Calcium (Ca2+) is a second messenger for many signal pathways, and changes in
intracellular Ca2+ concentration ([Ca2+] i) are an important signaling mechanism in the …

Lymphatic collecting vessels exhibit spontaneous phasic contractions that are critical for
lymph propulsion and tissue fluid homeostasis. This rhythmic activity is driven by action …