IGSF8 is an innate immune checkpoint and cancer immunotherapy target

Y Li, X Wu, C Sheng, H Liu, H Liu, Y Tang, C Liu… - Cell, 2024 - cell.com
Antigen presentation defects in tumors are prevalent mechanisms of adaptive immune
evasion and resistance to cancer immunotherapy, whereas how tumors evade innate …

The Structural Basis for Recognition of Human Leukocyte Antigen Class I Molecules by the Pan-HLA Antibody W6/32

P Pymm, PM Saunders, S Anand… - The Journal of …, 2024 - journals.aai.org
The central immunological role of HLA class I (HLA-I) in presenting peptide Ags to cellular
components of the immune system has been the focus of intense study for> 60 y. A …

[HTML][HTML] Single-cell landscape of immunological responses in elderly patients with sepsis

W He, C Yao, K Wang, Z Duan… - Immunity & …, 2024 - immunityageing.biomedcentral.com
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays
a crucial role in its pathogenesis. Elderly patients, a special population influenced by …

[HTML][HTML] Diversity in the HLA-I Recognition of HLA-F Monoclonal Antibodies: HLA-F or HLA-Ib Monospecific, HLA-E or HLA-G Bispecific Antibodies with or without HLA …

MH Ravindranath, NM Ravindranath… - Antibodies, 2024 - mdpi.com
Previous investigators have used various anti-HLA-F monoclonal antibodies (mAbs) to
demonstrate that the tissue distribution of HLA-F is highly restricted. Notably, these mAbs …

Defining innate immune checkpoints controlling Natural Killer cell recognition of melanoma cells

T Hofman - 2024 - archiv.ub.uni-heidelberg.de
Melanoma, though rare, stands as one of the most lethal forms of skin cancer. Immune
checkpoint inhibitors targeting inhibitory receptors on T cells represent an effective therapy …

[PDF][PDF] Receptor patterns and function of γδT cells during healthy human pregnancy

NJ Maximilian - 2024 - pea.lib.pte.hu
In the mid-20th century, when fundamental mechanisms for transplantation were discovered,
Nobel Prize Laureate Peter Medawar realized parallels between an implanted embryo in …

[引用][C] Nachweis von Immuncheckpoints auf Monozyten und deren Veränderung bei Patienten mit Magenkarzinom

MK Weyh - 2024 - ul.qucosa.de
AML akute myeloische Leukämie ANGPTL engl. Angiopoetin-like-Protein APC
Allopyhococyanin APF antigenpräsentierende Funktion APZ Antigenpräsentierende Zelle …