Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry

KJM Benjamin, Q Chen, NJ Eagles… - Nature …, 2024 - nature.com
Ancestral differences in genomic variation affect the regulation of gene expression; however,
most gene expression studies have been limited to European ancestry samples or adjusted …

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease

SB Fass, B Mulvey, R Chase, W Yang… - Biology of Sex …, 2024 - Springer
Background Sex differences in the brain may play an important role in sex-differential
prevalence of neuropsychiatric conditions. Methods In order to understand the …

Network-based drug repurposing for schizophrenia

TTT Truong, ZSJ Liu, B Panizzutti, JH Kim… - …, 2024 - nature.com
Despite recent progress, the challenges in drug discovery for schizophrenia persist.
However, computational drug repurposing has gained popularity as it leverages the wealth …

[HTML][HTML] Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease

K Nordengen, C Cappelletti, S Bahrami, O Frei… - Brain, 2024 - ncbi.nlm.nih.gov
Parkinson's disease is an age-related neurodegenerative disorder with a higher incidence
in males than females. The causes for this sex difference are unknown. Genome-wide …

[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain

MR de Los Santos, BH Kopell, AB Grice, G Ganesh… - medRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …

Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions

V Pak, Q Adewale, D Bzdok, M Dadar, Y Zeighami… - Elife, 2024 - elifesciences.org
For over a century, brain research narrative has mainly centered on neuron cells.
Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their …

Divergent landscapes of A-to-I editing in postmortem and living human brain

M Rodriguez de los Santos, BH Kopell… - medRxiv, 2024 - medrxiv.org
Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification
within the brain. Yet, most research has relied on postmortem samples, assuming it is an …

Transcriptomic analysis of the human habenula in schizophrenia

EA Yalcinbas, B Ajanaku, ED Nelson, R Garcia-Flores… - bioRxiv, 2024 - biorxiv.org
Importance: Habenula (Hb) pathophysiology is involved in many neuropsychiatric disorders,
including schizophrenia. Deep brain stimulation and pharmacological targeting of the Hb …