Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
KJM Benjamin, Q Chen, NJ Eagles… - Nature …, 2024 - nature.com
Ancestral differences in genomic variation affect the regulation of gene expression; however,
most gene expression studies have been limited to European ancestry samples or adjusted …
most gene expression studies have been limited to European ancestry samples or adjusted …
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease
Background Sex differences in the brain may play an important role in sex-differential
prevalence of neuropsychiatric conditions. Methods In order to understand the …
prevalence of neuropsychiatric conditions. Methods In order to understand the …
Network-based drug repurposing for schizophrenia
Despite recent progress, the challenges in drug discovery for schizophrenia persist.
However, computational drug repurposing has gained popularity as it leverages the wealth …
However, computational drug repurposing has gained popularity as it leverages the wealth …
[HTML][HTML] Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease
Parkinson's disease is an age-related neurodegenerative disorder with a higher incidence
in males than females. The causes for this sex difference are unknown. Genome-wide …
in males than females. The causes for this sex difference are unknown. Genome-wide …
[HTML][HTML] Divergent landscapes of A-to-I editing in postmortem and living human brain
MR de Los Santos, BH Kopell, AB Grice, G Ganesh… - medRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA
modification within the brain. Yet, most research has relied on postmortem samples …
modification within the brain. Yet, most research has relied on postmortem samples …
Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions
For over a century, brain research narrative has mainly centered on neuron cells.
Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their …
Accordingly, most neurodegenerative studies focus on neuronal dysfunction and their …
Divergent landscapes of A-to-I editing in postmortem and living human brain
M Rodriguez de los Santos, BH Kopell… - medRxiv, 2024 - medrxiv.org
Adenosine-to-inosine (A-to-I) editing is a prevalent post-transcriptional RNA modification
within the brain. Yet, most research has relied on postmortem samples, assuming it is an …
within the brain. Yet, most research has relied on postmortem samples, assuming it is an …
Transcriptomic analysis of the human habenula in schizophrenia
EA Yalcinbas, B Ajanaku, ED Nelson, R Garcia-Flores… - bioRxiv, 2024 - biorxiv.org
Importance: Habenula (Hb) pathophysiology is involved in many neuropsychiatric disorders,
including schizophrenia. Deep brain stimulation and pharmacological targeting of the Hb …
including schizophrenia. Deep brain stimulation and pharmacological targeting of the Hb …