Spectral signatures of psilocybin, lysergic acid diethylamide (LSD) and ketamine in healthy volunteers and persons with major depressive disorder and treatment …

GH Le, S Wong, S Badulescu, H Au… - Journal of Affective …, 2024 - Elsevier
Background Electrophysiologic measures provide an opportunity to inform mechanistic
models and possibly biomarker prediction of response. Serotonergic psychedelics (SPs)(ie …

Subanaesthetic ketamine suppresses locus coeruleus mediated alertness effects-a 7T fMRI study

T Liebe, LV Danyeli, ZD Sen, M Li… - International Journal …, 2024 - academic.oup.com
Background The NMDA antagonist s-ketamine is gaining increasing use as a rapid-acting
antidepressant, although its exact mechanisms of action are still unknown. In this study, we …

Mechanism of Antidepressant Action of (2R, 6R)-6-Hydroxynorketamine (HNK) and Its Compounds: Insights from Proteomic Analysis

C Zhen, C Wang, Y Ma, Y Pang, F Cai, J Meng… - Molecular …, 2024 - Springer
The effects of HNK, I5, and I6 on the expression of protein in hippocampus of depressed
mice were studied by isobaric tags for relative and absolute quantitation (iTRAQ) to explore …