11β‐Hydroxysteroid dehydrogenase and the brain: Not (yet) lost in translation

J Seckl - Journal of Internal Medicine, 2024 - Wiley Online Library
beta‐hydroxysteroid dehydrogenases (11β‐HSDs) catalyse the conversion of active 11‐
hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11‐keto forms (cortisone, 11 …

Recent strategies for improving MALDI mass spectrometry imaging performance towards low molecular weight compounds

Z Sun, F Wang, Y Liu, B Deng, R Ren, Y Wang… - TrAC Trends in …, 2024 - Elsevier
Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI),
traditionally used for analyzing larger molecules, faces challenges with low molecular …

[HTML][HTML] Improved on-tissue detection of the anti-cancer agent doxorubicin by quantitative matrix-assisted laser desorption/ionization mass spectrometry imaging

CXL Van Assche, DN Krüger, B Flinders… - Talanta, 2024 - Elsevier
Doxorubicin (dox) is an affordable, and highly effective chemotherapeutic agent used in
cancer treatment, yet its application is known to cause cumulative cardiac and renal toxicity …

Vacuum promoted on-tissue derivatization strategy: Unravelling spatial distribution of glycerides on tissue

YQ Cao, YJ Lu, L Zhang, J Zhang, YL Guo - Chinese Chemical Letters, 2024 - Elsevier
Matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI) has
shown its capability in visualizing the spatial distribution of various kinds of endogenous …

Spatial neurolipidomics—MALDI mass spectrometry imaging of lipids in brain pathologies

D Jha, K Blennow, H Zetterberg… - Journal of Mass …, 2024 - Wiley Online Library
Given the complexity of nervous tissues, understanding neurochemical pathophysiology
puts high demands on bioanalytical techniques with respect to specificity and sensitivity …

Vitamin D tissue distribution by mass spectrometry imaging

DF Cobice, KW Smith - Feldman and Pike's Vitamin D, 2024 - Elsevier
Knowing the distribution of vitamin D metabolites at the tissue level may provide very
valuable information in the understanding of the synthesis and function of these metabolites …