Neurodevelopmental disorders (NDDs) are associated with a wide range of clinical features,
affecting multiple pathways involved in brain development and function. Recent advances in …

The inaccessibility of neurons coming directly from patients has hindered our understanding
of mental illnesses at the cellular level. To overcome this obstacle, six different cellular …

Abstract Synaptotagmin-1 (Syt1) is a presynaptic calcium sensor with two calcium binding
domains, C2A and C2B, that triggers action potential-induced synchronous neurotransmitter …

Background A growing body of evidence suggests that immune dysfunction and
inflammation in the peripheral tissues as well as the central nervous system are associated …

Autism spectrum disorder (ASD) affects 1 in 36 people and is more often diagnosed in males
than in females. Core features of ASD are impaired social interactions, repetitive behaviors …

Neurodevelopmental disorders (NDDs) include a broad spectrum of pathological conditions
that affect> 4% of children worldwide, share common features and present a variegated …

Autism spectrum disorder (ASD) is defined by common behavioral characteristics, raising
the possibility of shared pathogenic mechanisms. Yet, vast clinical and etiological …

BACKGROUND: The UBE2A protein belongs to the E2 family of ubiquitin-binding enzymes
involved in the ubiquitination of substrate proteins. Mutations in the UBE2A gene lead to …