Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy

Y Wu, J De Asis-Cruz, C Limperopoulos - Molecular Psychiatry, 2024 - nature.com
In-utero exposure to maternal psychological distress is increasingly linked with disrupted
fetal and neonatal brain development and long‐term neurobehavioral dysfunction in …

Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders

E Kim, JR Huh, GB Choi - Nature Immunology, 2024 - nature.com
The intricate relationship between immune dysregulation and neurodevelopmental
disorders (NDDs) has been observed across the stages of both prenatal and postnatal …

The influence of early-life adversity on the coupling of structural and functional brain connectivity across childhood

SY Chan, ZM Ngoh, ZY Ong, AL Teh, MZL Kee… - Nature Mental …, 2024 - nature.com
Early-life adversity (ELA) exposure is suggested to accelerate development. However, the
influence of ELA on neurodevelopmental trajectories has not been assessed directly but …

Sex-Specific Pathways From Prenatal Maternal Inflammation to Adolescent Depressive Symptoms

E Lipner, N Mac Giollabhui, EC Breen, BA Cohn… - JAMA …, 2024 - jamanetwork.com
Importance Prenatal maternal inflammation has been associated with major depressive
disorder in offspring in adulthood as well as with internalizing and externalizing symptoms in …

Cumulative effects of resting-state connectivity across all brain networks significantly correlate with attention-deficit hyperactivity disorder symptoms

MA Mooney, RJM Hermosillo, E Feczko… - Journal of …, 2024 - Soc Neuroscience
Identification of replicable neuroimaging correlates of attention-deficit hyperactivity disorder
(ADHD) has been hindered by small sample sizes, small effects, and heterogeneity of …

The Role of IL-6 in Neurodegenerative Disorders

C Shan, C Zhang, C Zhang - Neurochemical Research, 2024 - Springer
Abstract “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive
neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6) …

Pulmonary maternal immune activation does not cross the placenta but leads to fetal metabolic adaptation

SSK Hansen, R Krautz, D Rago, J Havelund… - Nature …, 2024 - nature.com
The fetal development of organs and functions is vulnerable to perturbation by maternal
inflammation which may increase susceptibility to disorders after birth. Because it is not well …

Prenatal exposure to maternal disadvantage-related inflammatory biomarkers: associations with neonatal white matter microstructure

AFP Sanders, B Tirado, NA Seider, RL Triplett… - Translational …, 2024 - nature.com
Prenatal exposure to heightened maternal inflammation has been associated with adverse
neurodevelopmental outcomes, including atypical brain maturation and psychiatric illness …

Autism spectrum disorder: Pathogenesis, biomarker, and intervention therapy

H Zhuang, Z Liang, G Ma, A Qureshi, X Ran… - MedComm, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) has become a common neurodevelopmental disorder. The
heterogeneity of ASD poses great challenges for its research and clinical translation. On the …

Immune alterations in the intrauterine environment shapes offspring brain development in a sex-specific manner

E Guma, MM Chakravarty - Biological Psychiatry, 2024 - Elsevier
Exposure to inflammation in utero or in early life is known to increase risk for
neuropsychiatric illness. The sources of inflammation can be varied, including acute …