In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase

L Shang, H Wei, J Deng, MJ Stewart, JE LeSaint… - Scientific Reports, 2024 - nature.com
It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …

Structure-based design and discovery of long-acting cocaine hydrolase mutants with improved binding affinity to neonatal fc receptor for treatment of substance use …

CG Zhan, F Zheng - US Patent App. 18/268,575, 2024 - Google Patents
US20240041989A1 - Structure-based design and discovery of long-acting cocaine
hydrolase mutants with improved binding affinity to neonatal fc receptor for treatment of …