Early stages of deadly respiratory diseases including COVID-19 are challenging to elucidate
in humans. Here, we define cellular tropism and transcriptomic effects of SARS-CoV-2 virus …

Cystic fibrosis (CF) is a fatal autosomal recessive disorder caused by the loss of function
mutations within a single gene for the Cystic Fibrosis Transmembrane Conductance …

Since the advent of single-cell RNA sequencing (scRNA-seq) methodology, single-cell
analysis has become a powerful tool for exploration of cellular networks and dysregulated …

Batch effects in single-cell RNA-seq data pose a significant challenge for comparative
analyses across samples, individuals, and conditions. Although batch effect correction …

Background Macrophages are the predominant immune cells in the human lung and play a
central role in airway inflammation, including asthma and chronic obstructive pulmonary …

Microbiota play a critical role in the development and training of host innate and adaptive
immunity. We present the cellular landscape of the upper airway, specifically the larynx, by …

Early career members of Assembly 3 (Basic and Translational Sciences) of the European
Respiratory Society (ERS) summarise the key messages discussed during six selected …

Epithelium-derived cytokines or alarmins, such as interleukin-33 (IL-33) and thymic stromal
lymphopoietin (TSLP), are major players in type 2 immunity and asthma. Here, we …

Understanding the molecular and cellular processes involved in lung epithelial regeneration
may fuel the development of therapeutic approaches for lung diseases. We combine mouse …

Despite their importance for immunity against sexually transmitted infections, the
composition of female reproductive tract (FRT) memory T-cell populations in response to …