Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment
Y Zhang, H Ma, Y Bai, X Hou, Y Yang… - ACS Chemical …, 2024 - ACS Publications
Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide
health problem that affects the quality of life of patients and imposes a tremendous …
health problem that affects the quality of life of patients and imposes a tremendous …
Translocator protein 18 kDa (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate
RA Cazuza, SM Zagrai, AR Grieco, TD Avery… - Brain, Behavior, and …, 2024 - Elsevier
Neuroimmune signaling is a key process underlying neuropathic pain. Clinical studies have
demonstrated that translocator protein 18 kDa (TSPO), a putative marker of …
demonstrated that translocator protein 18 kDa (TSPO), a putative marker of …
Nerve Injury Triggers Time-dependent Activation of the Locus Coeruleus, Influencing Spontaneous Pain-like Behavior in Rats
I Suárez-Pereira, C López-Martín… - …, 2024 - pubs.asahq.org
Background Dynamic changes in neuronal activity and in noradrenergic locus coeruleus
(LC) projections have been proposed during the transition from acute to chronic pain. Thus …
(LC) projections have been proposed during the transition from acute to chronic pain. Thus …
Neural circuit-selective, multiplexed pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception
CC Kuo, JG McCall - bioRxiv, 2024 - biorxiv.org
Selective manipulation of neural circuits using optogenetics and chemogenetics holds great
translational potential but requires genetic access to neurons. Here, we demonstrate a …
translational potential but requires genetic access to neurons. Here, we demonstrate a …
Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain
K Jiao, Z Ma, Q Wan, W Qin, W Qin, J Yan, Y Zhu… - 2024 - researchsquare.com
Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied
by pain, seriously affecting physical and mental health of patients. Abnormal innervation at …
by pain, seriously affecting physical and mental health of patients. Abnormal innervation at …