[HTML][HTML] Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Inflammatory liver diseases and susceptibility to sepsis

H Lu - Clinical Science, 2024 - portlandpress.com
Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and
metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of …

[HTML][HTML] Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis

H Sajiir, S Keshvari, KY Wong, DJ Borg… - Nature …, 2024 - nature.com
Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver
disease worldwide, with a single approved therapeutic. Previous research has shown that …

Gut-liver Axis: Recent concepts in pathophysiology in alcohol-associated liver disease

FR Tonetti, A Eguileor, M Mrdjen, V Pathak… - Hepatology, 2024 - journals.lww.com
The growing recognition of the role of the gut microbiome's impact on alcohol-related
diseases, especially in alcohol-associated liver disease, emphasizes the need to …

IL-22, a vital cytokine in autoimmune diseases

J Li, Z Wu, Y Wu, XY Hu, J Yang, D Zhu… - Clinical and …, 2024 - academic.oup.com
Summary Interleukin-22 (IL-22) is a vital cytokine that is dysregulated in various autoimmune
conditions including rheumatoid arthritis (RA), multiple sclerosis (MS), and Alzheimer's …

[HTML][HTML] Bacillus coagulans regulates gut microbiota and ameliorates the alcoholic-associated liver disease in mice

T Liu, Z Zhang - Frontiers in Microbiology, 2024 - frontiersin.org
Introduction Alcoholic-associated liver diseases (ALD) are now widespread issues
worldwide. Alcoholic-induced chronic dysbiosis of the gut microbiota is one of the factors in …

Lipid-encapsulated mRNA encoding an extended serum half-life interleukin-22 ameliorates metabolic disease in mice

S Canali, AW Fischer, M Nguyen, K Anderson, L Wu… - Molecular …, 2024 - Elsevier
Abstract Objective Interleukin (IL)-22 is a potential therapeutic protein for the treatment of
metabolic diseases such as obesity, type 2 diabetes, and metabolic dysfunction-associated …

[HTML][HTML] Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases

SG Rodrigues, S van der Merwe, A Krag… - Seminars in immunology, 2024 - Elsevier
“A healthy liver stands on a healthy gut” with the gut and its barriers representing the roots
that fuel the liver and expose it to an amazing diverse mixture of gut-derived material/agents …

Inflammation in alcohol-associated hepatitis: pathogenesis and therapeutic targets

D Feng, S Hwang, A Guillot, Y Wang, Y Guan… - Cellular and Molecular …, 2024 - Elsevier
Alcohol-associated hepatitis (AH) is an acute-on-chronic liver injury that occurs in patients
with chronic alcohol-associated liver disease (ALD). Patients with severe AH have high short …

The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease

GGM Scarlata, C Colaci, M Scarcella, M Dallio… - Diseases, 2024 - mdpi.com
Alcoholic liver disease (ALD) is a major cause of chronic liver disease. This term covers a
broad spectrum of liver lesions, from simple steatosis to alcoholic hepatitis and cirrhosis. The …