Cancer cell plasticity plays a crucial role in tumor initiation, progression, and metastasis and
is implicated in the multiple cancer defense mechanisms associated with therapy resistance …

COVID-19 is a global health threat caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is associated with a significant increase in morbidity and …

Ethnopharmacological relevance Eriocephalus africanus infusion is used as a diuretic and a
diaphoretic and is also used in the treatment of gastrointestinal disorders and …

Ischemic stroke is the leading cause of death and disability worldwide. Nevertheless, there
still lacks the effective therapies for ischemic stroke. Microglia are resident macrophages of …

Background The pathogenesis of acute liver injury (ALI) has been a pressing issue in the
medical scientific community. We previously found that 5-O-methylvisammioside (MeV) from …

HIV cure still remains an elusive target. The “Shock and Kill” strategy which aims to
reactivate HIV from latently infected cells and subsequently kill them through virally induced …

Background & Aims Dysregulated colonic epithelial cell (CEC) proliferation is a critical
feature in the development of colorectal cancer. We show that NF-κB-inducing kinase (NIK) …

The health risks associated with exposure to heavy metals, such as Pb 2+, are increasingly
concerning the public. Pb 2+ can cause significant harm to the human body through …

IKKα, encoded by CHUK, is crucial in the non-canonical NF-κB pathway and part of the IKK
complex activating the canonical pathway alongside IKKβ. Absence of IKKα cause fetal …

The disruption of antiviral sensors and the evasion of immune defences by various tactics
are hallmarks of EBV infection. One of the EBV latent gene products, LMP1, was shown to …