Cholestasis is the predominate feature of many pediatric hepatobiliary diseases. The
physiologic flow of bile requires multiple complex processes working in concert. Bile acid …

Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver malignancy. The
interplay between bile acids (BAs) and the gut microbiota has emerged as a critical factor in …

Ferroptosis, as a novel regulable cell death, is characterized by iron overload, glutathione
depletion, and an accumulation of lipid peroxides. Recently, it has been discovered that …

Bis (2-ethylhexyl)-tetrabromophthalate (TBPH), a typical novel brominated flame retardant,
has been ubiquitously identified in various environmental and biotic media. Consequently …

Emerging evidence reveal that tumor-associated bacteria (TAB) can facilitate the initiation
and progression of multiple types of cancer. Recent work has emphasized the significant …

Bile acids (BAs) are signaling molecules synthesized in the liver initially by CYP7A1 and
CYP27A1 in the classical and alternative pathways, respectively. BAs are essential for …

Chronic cholestatic damage is associated to both accumulation of cytotoxic levels of bile
acids and expansion of adult hepatic progenitor cells (HPC) as part of the ductular reaction …

Bile acids help facilitate intestinal lipid absorption and have endocrine activity in glucose,
lipid and bone metabolism. Obesity and exercise influence bile acid metabolism and have …

Polybrominated diphenyl ethers (PBDEs) are legacy flame retardants that bioaccumulate in
the environment. The gut microbiome is an important regulator of liver functions including …

Objective To investigate the diagnostic and prognostic value of the Systemic Inflammation
Response Index (SIRI) in intrahepatic cholestasis of pregnancy (ICP). Methods The present …