A DNA Force Circuit for Exploring Protein‐Protein Interactions at the Single‐Molecule Level

K Ma, L Xiong, Z Wang, X Hu, L Qu… - Chinese Journal of …, 2024 - Wiley Online Library
Comprehensive Summary Protein‐protein interactions (PPIs) play a crucial role in drug
discovery and disease treatment. However, the development of effective drugs targeting …

[HTML][HTML] Robust, high-yield, rapid fabrication of DNA constructs for Magnetic Tweezers

P Strzelecki, A Shpiruk, GM Cech, A Kloska… - Biochemical and …, 2024 - Elsevier
Single-molecule techniques are highly sensitive tools that can reveal reaction intermediates
often obscured in experiments involving large ensembles of molecules. Therefore, they …

Exploring the free energy landscape of proteins using magnetic tweezers.

H Sun, S Le, Z Guo, H Chen - Methods in Enzymology, 2024 - europepmc.org
Proteins fold to their native states by searching through the free energy landscapes. As
single-domain proteins are the basic building block of multiple-domain proteins or protein …

Quantifying the conformations of sequence-defined polymers through entropic elasticity measurements

HP Truong - 2024 - escholarship.org
Intrinsically disordered proteins (IDPs) do not adopt a stable three-dimensional structure,
thus posing a challenge to common characterization techniques that have found success …

High-speed measurements of SNARE-complexin interactions using magnetic tweezers.

S Hong, T Yang, A Go, H Kim, TY Yoon… - Methods in …, 2024 - europepmc.org
In neuroscience, understanding the mechanics of synapses, especially the function of force-
sensitive proteins at the molecular level, is essential. This need emphasizes the importance …

[PDF][PDF] Results in Chemistry

Y Ajaj, ZH Mahmoud, AN Obeed, M Al-Salih… - researchgate.net
Molecular motor can be defined as the collection of a separate number of molecular features
(that is, a supramolecular structure) which has been developed to carry out a function …