Precursor lesions in familial and hereditary pancreatic cancer

MJ Pflüger, LAA Brosens, RH Hruban - Familial Cancer, 2024 - Springer
Infiltrating ductal adenocarcinoma of the pancreas, referred to here as “pancreatic cancer,” is
one of the deadliest of all of the solid malignancies. The five-year survival rate in the United …

3D genomic mapping reveals multifocality of human pancreatic precancers

AM Braxton, AL Kiemen, MP Grahn, A Forjaz… - Nature, 2024 - nature.com
Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of
pancreatic cancer, but their small size and inaccessibility in humans make them challenging …

Neoplastic Progression in Macroscopic Precursor Lesions of the Pancreas

ED Thompson - Archives of Pathology & Laboratory …, 2024 - meridian.allenpress.com
Context.—Macroscopic precursor lesions of the pancreas represent a complex clinical
management problem. Molecular characterization of pancreatic cysts has helped to confirm …

[HTML][HTML] Intraductal papillary mucinous neoplasms in high-risk individuals: incidence, growth rate, and malignancy risk

KA Overbeek, BDM Koopmann, IJM Levink… - Clinical …, 2024 - Elsevier
Background and Aims In high-risk individuals (HRIs), we aimed to assess the cumulative
incidence of intraductal papillary mucinous neoplasms (IPMNs) and compare IPMN growth …

Molecular Pathology of Pancreatic Cystic Lesions with a Focus on Malignant Progression

Y Hu, D Jones, AK Esnakula, SG Krishna, W Chen - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic cysts are being identified with increasing frequency, and the
prevalence increases with age to 10–25% by the 7th decade of life. They also have the …

Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches

M Gu, Y Liu, P Xin, W Guo, Z Zhao, X Yang, R Ma… - Cancer Letters, 2024 - Elsevier
The gastrointestinal tract can be affected by a number of diseases that pancreatic cancer
(PC) is a malignant manifestation of them. The prognosis of PC patients is unfavorable and …

Intraductal Papillary Mucinous Neoplasm Surveillance Leads to Early Diagnosis and Better Outcomes of Concomitant Cancer

H Oyama, T Hamada, Y Nakai, M Tanaka… - Annals of …, 2024 - journals.lww.com
Objective: To examine whether long-term surveillance of intraductal papillary mucinous
neoplasms (IPMNs) leads to early diagnosis and better clinical outcomes of pancreatic …

Inadequacy of the eighth edition of the American Joint Committee on Cancer pancreatic cancer staging system for invasive carcinoma associated with premalignant …

HS Jung, M Lee, Y Han, AS Thomas, WG Yun, YJ Cho… - HPB, 2024 - Elsevier
Background Invasive carcinomas arising from premalignant lesions are currently staged by
the same criteria as conventional pancreatic ductal adenocarcinoma. Methods …

Is multidisciplinary treatment effective for invasive intraductal papillary mucinous carcinoma?

S Hirono, R Higuchi, G Honda, S Nara… - Annals of …, 2024 - Wiley Online Library
Background Surgical resection is standard treatment for invasive intraductal papillary
mucinous carcinoma (IPMC); however, impact of multidisciplinary treatment on survival …

The Revised Kyoto Criteria and Risk of Malignancy Among Patients With Intraductal Papillary Mucinous Neoplasms

T Hamada, H Oyama, S Tange, R Hakuta… - Clinical …, 2024 - Elsevier
Abstract Background & Aims The revised Kyoto guidelines have a new catalog of high-risk
stigmata and worrisome features for the risk stratification of intraductal papillary mucinous …