Physiological functions of RIG-I-like receptors

M Yoneyama, H Kato, T Fujita - Immunity, 2024 - cell.com
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …

A‐to‐I RNA editing by ADAR and its therapeutic applications: From viral infections to cancer immunotherapy

R Datta, JZ Adamska, A Bhate… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
ADAR deaminases catalyze adenosine‐to‐inosine (A‐to‐I) editing on double‐stranded RNA
(dsRNA) substrates that regulate an umbrella of biological processes. One of the two …

[HTML][HTML] UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors

D Yang, T Geng, AG Harrison, JG Cahoon… - Nature …, 2024 - nature.com
Abstract The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral
RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected …

[HTML][HTML] p53 promotes antiviral innate immunity by driving hexosamine metabolism

W Xia, P Jiang - Cell Reports, 2024 - cell.com
The tumor suppressor p53 controls cell fate decisions and prevents malignant
transformation, but its functions in antiviral immunity remain unclear. Here, we demonstrate …

Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15

F Ito, H Yang, ZH Zhou, XS Chen - Protein & Cell, 2024 - academic.oup.com
Coronaviruses have evolved a wide array of tactics to evade host antiviral immunity. When
host cells detect invading foreign nucleic acids including viral genome and viral replication …

Control of adaptive immunity by pattern recognition receptors

SL Carroll, C Pasare, GM Barton - Immunity, 2024 - cell.com
One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …

Lipid nanoparticle encapsulation empowers poly (I: C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

A Lamoot, S Jangra, G Laghlali, P Warang, G Singh… - Small, 2024 - Wiley Online Library
Poly (I: C) is a synthetic analogue of dsRNA capable of activating both TLR3 and RLRs,
such as MDA‐5 and RIG‐I, as pathogen recognition receptors. While poly (I: C) is known to …

G3BP1-dependent condensation of translationally inactive viral RNAs antagonizes infection

JM Burke, OC Ratnayake, JM Watkins, R Perera… - Science …, 2024 - science.org
G3BP1 is an RNA binding protein that condenses untranslating messenger RNAs into stress
granules (SGs). G3BP1 is inactivated by multiple viruses and is thought to antagonize viral …

[HTML][HTML] ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection

LE Bazzone, J Zhu, M King, GQ Liu, Z Guo… - Nature …, 2024 - nature.com
Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and
mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis …

Effective synthesis of circRNA via a thermostable T7 RNA polymerase variant as the catalyst

W He, X Zhang, Y Zou, J Li, L Chang, YC He… - … in Bioengineering and …, 2024 - frontiersin.org
Introduction: Circular RNAs (circRNAs) are endogenous noncoding RNAs (ncRNAs) with
transcriptional lengths ranging from hundreds to thousands. circRNAs have attracted …