Physiological functions of RIG-I-like receptors
M Yoneyama, H Kato, T Fujita - Immunity, 2024 - cell.com
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …
responses and have immense physiological importance. In this review, we first summarize …
A‐to‐I RNA editing by ADAR and its therapeutic applications: From viral infections to cancer immunotherapy
ADAR deaminases catalyze adenosine‐to‐inosine (A‐to‐I) editing on double‐stranded RNA
(dsRNA) substrates that regulate an umbrella of biological processes. One of the two …
(dsRNA) substrates that regulate an umbrella of biological processes. One of the two …
[HTML][HTML] UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors
D Yang, T Geng, AG Harrison, JG Cahoon… - Nature …, 2024 - nature.com
Abstract The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral
RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected …
RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected …
[HTML][HTML] p53 promotes antiviral innate immunity by driving hexosamine metabolism
W Xia, P Jiang - Cell Reports, 2024 - cell.com
The tumor suppressor p53 controls cell fate decisions and prevents malignant
transformation, but its functions in antiviral immunity remain unclear. Here, we demonstrate …
transformation, but its functions in antiviral immunity remain unclear. Here, we demonstrate …
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15
Coronaviruses have evolved a wide array of tactics to evade host antiviral immunity. When
host cells detect invading foreign nucleic acids including viral genome and viral replication …
host cells detect invading foreign nucleic acids including viral genome and viral replication …
Control of adaptive immunity by pattern recognition receptors
One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …
recognition that signals from the innate immune system are required for induction of …
Lipid nanoparticle encapsulation empowers poly (I: C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity
Poly (I: C) is a synthetic analogue of dsRNA capable of activating both TLR3 and RLRs,
such as MDA‐5 and RIG‐I, as pathogen recognition receptors. While poly (I: C) is known to …
such as MDA‐5 and RIG‐I, as pathogen recognition receptors. While poly (I: C) is known to …
G3BP1-dependent condensation of translationally inactive viral RNAs antagonizes infection
G3BP1 is an RNA binding protein that condenses untranslating messenger RNAs into stress
granules (SGs). G3BP1 is inactivated by multiple viruses and is thought to antagonize viral …
granules (SGs). G3BP1 is inactivated by multiple viruses and is thought to antagonize viral …
[HTML][HTML] ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection
Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and
mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis …
mortality. Type I interferon (IFN)-mediated antiviral responses protect against myocarditis …
Effective synthesis of circRNA via a thermostable T7 RNA polymerase variant as the catalyst
W He, X Zhang, Y Zou, J Li, L Chang, YC He… - … in Bioengineering and …, 2024 - frontiersin.org
Introduction: Circular RNAs (circRNAs) are endogenous noncoding RNAs (ncRNAs) with
transcriptional lengths ranging from hundreds to thousands. circRNAs have attracted …
transcriptional lengths ranging from hundreds to thousands. circRNAs have attracted …