Human genetics has emerged as one of the most dynamic areas of biology, with a
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …

Objectives ABO blood types have widespread clinical use and robust associations with
disease. The purpose of this study is to evaluate the portability and suitability of tag single …

Background The term eGene has been applied to define a gene whose expression level is
affected by at least one independent expression quantitative trait locus (eQTL). It is both …

Polygenic scores (PGSs) provide an individual level estimate of genetic risk for any given
disease. Since most PGSs have been derived from genome wide association studies …

Background Approximately 95% of samples analyzed in univariate genome-wide
association studies (GWAS) are of European ancestry. This bias toward European ancestry …

Crohn's disease (CD) is regarded as a lifelong progressive disease affecting all segments of
the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) …

Vascular cognitive impairment (VCI) is a heterogenous form of cognitive impairment that
results from cerebrovascular disease. It is a result of both genetic and non‐genetic factors …

Psychiatric disorders have a great impact in terms of mortality, morbidity, and disability
across the lifespan. Considerable effort has been devoted to understanding their complex …

Background Colorectal cancer is the second leading cause of cancer-related fatalities.
Recent genome-wide association studies (GWAS) identified genetic loci implicated in …

The majority of human complex traits are underscored by a combination of genetic and
environmental factors. Epigenetic mechanisms such as DNA methylation (DNAm) capture …