A review of moxidectin vs. other macrocyclic lactones for prevention of heartworm disease in dogs with an appraisal of two commercial formulations
K Mwacalimba, J Sheehy, C Adolph… - Frontiers in Veterinary …, 2024 - frontiersin.org
Macrocyclic lactones (MLs) are the only drug class currently licensed for heartworm disease
prophylaxis. Macrocyclic lactones kill third-and fourth-stage larvae of Dirofilaria immitis, thus …
prophylaxis. Macrocyclic lactones kill third-and fourth-stage larvae of Dirofilaria immitis, thus …
[HTML][HTML] Genome structure and population genomics of the canine heartworm Dirofilaria immitis
J Gandasegui, RI Power, E Curry, DCW Lau… - International Journal for …, 2024 - Elsevier
The heartworm, Dirofilaria immitis, is a filarial parasitic nematode responsible for significant
morbidity and mortality in wild and domesticated canids. Resistance to macrocyclic lactone …
morbidity and mortality in wild and domesticated canids. Resistance to macrocyclic lactone …
Genotyping USA laboratory-maintained isolates and European clinical isolates of Dirofilaria immitis to assess macrocyclic lactone susceptibility or resistance at …
S Kumar, H Che, R Chiummo, L Heuer… - Veterinary …, 2024 - Elsevier
Dirofilaria immitis is a parasitic nematode that causes cardiovascular dirofilariosis ("
heartworm disease”) primarily in canids. The principal approach for mitigating heartworm …
heartworm disease”) primarily in canids. The principal approach for mitigating heartworm …
[HTML][HTML] Exploring multiplex qPCR as a diagnostic tool for detecting microfilarial DNA in dogs infected with Dirofilaria immitis: A comparative analysis with the modified …
Current recommendations to diagnose cardiopulmonary dirofilariosis in dogs caused by
Dirofilaria immitis involves tandem antigen and circulating microfilariae tests. The modified …
Dirofilaria immitis involves tandem antigen and circulating microfilariae tests. The modified …
Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes
Background Filarial nematodes cause severe illnesses in humans and canines including
limb deformities and disfigurement, heart failure, blindness, and death, among others. There …
limb deformities and disfigurement, heart failure, blindness, and death, among others. There …
[HTML][HTML] First case of macrocyclic lactone-resistant Dirofilaria immitis in Europe-Cause for concern
D Traversa, A Diakou, M Colombo, S Kumar… - International Journal for …, 2024 - Elsevier
Heartworm disease caused by the nematode Dirofilaria immitis is one of the most important
parasitoses of dogs. The treatment of the infection is long, complicated, risky and expensive …
parasitoses of dogs. The treatment of the infection is long, complicated, risky and expensive …
[HTML][HTML] Investigating Dirofilaria immitis isolates infecting domestic canines and their susceptibility/resistance patterns to macrocyclic lactones in the northern region of …
PT Fisher, K Keller, RK Prichard - Veterinary Parasitology, 2024 - Elsevier
Previous reports of macrocyclic lactone (ML) resistance in Dirofilaria immitis, the parasitic
nematode which causes heartworm disease, have mainly been from the southern …
nematode which causes heartworm disease, have mainly been from the southern …
[HTML][HTML] Delayed canine heartworm (Dirofilaria immitis) microfilarial reduction following Advocate™ for dogs (imidacloprid, moxidectin) treatment
Macrocyclic lactone (ML) anthelmintics are currently the only class of drugs available for
canine heartworm prevention. Recent reports of Dirofilaria immitis infection occurring in …
canine heartworm prevention. Recent reports of Dirofilaria immitis infection occurring in …
[HTML][HTML] Whole genome amplification and sequencing of individual Dirofilaria immitis microfilariae
Dirofilaria immitis is a filarial parasitic nematode of veterinary significance. With the
emergence of drug-resistant isolates in the USA, it is imperative to determine the likelihood …
emergence of drug-resistant isolates in the USA, it is imperative to determine the likelihood …
Onchocerciasis Part I
BA Boatin, Y Dadzie, U Amazigo - Neglected Tropical Diseases-Sub …, 2024 - Springer
Onchocerciasis, also known as river blindness, is a dermic filariasis caused by the
nematode Onchocerca volvulus. The disease is found in 30 African countries between …
nematode Onchocerca volvulus. The disease is found in 30 African countries between …