Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing
the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding …

Introduction: Exosomes, pivotal in intercellular communication during skin disease
pathogenesis, have garnered substantial attention. However, the impact of environmental …

To identify novel susceptibility genes for hepatocellular carcinoma (HCC), we performed a
rare-variant association study in Chinese populations consisting of 2,750 cases and 4,153 …

Regulatory elements, particularly enhancers, play a crucial role in disease susceptibility and
progression. Enhancers are DNA sequences that activate gene expression and can be …

Background Psoriasis is a genetically determined systemic skin disease, although
environmental trigger factors are required for disease manifestation. Some of these triggers …

Background Multiple treatment options are available for the management of psoriasis, but
clinical response varies among individual patients and no biomarkers are available to …

Leprosy and psoriasis rarely coexist, the specific molecular mechanisms underlying their
mutual exclusion have not been extensively investigated. This study aimed to reveal the …

Abstract Background Psoriatic disease (PsD) is closely associated with cardiovascular
diseases. The Life's Essential 8 (LE8) score is a new metric for assessing cardiovascular …

The FUT2 gene encodes an enzyme called α-1, 2-fucosyltransferase, which is involved in
the formation of blood group antigens AB0 (H) and is also involved in the processes of …

Psoriasis is a multifactorial genetic disorder manifested by hyperproliferation and abnormal
differentiation of epidermal keratinocytes, along with the infiltration of inflammatory cells into …