Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly
individuals, especially postmenopausal women, are particularly susceptible to osteoporosis …

Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative
conditions with an assorted etiology and a highly complicated molecular mechanism that to …

Hip fractures are associated with significant disability, high cost, and mortality. However, the
exact biological mechanisms underlying susceptibility to hip fractures remain incompletely …

Large-scale genetic studies are reliably identifying many risk factors for disease in the
general population. Several of these genetic risk factors encode potential drug targets, and …

The causes of temporal fluctuations in adult traits are poorly understood. Here, we
investigate the genetic determinants of within-person trait variability of 8 repeatedly …

Introduction Gut microbiota (GM) is the collection of small organisms such as bacteria, fungi,
bacteriophages and protozoans living in the intestine in symbiotics relation within their host …

As there are effective treatments to reduce hip fractures, identification of patients at high risk
of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for …

EN1 encodes a homeodomain-containing transcription factor and is a determinant of bone
density and fracture. Previous powerful genome-wide association studies (GWASs) have …

Osteoarthritis (OA) is the most prevalent disorder of synovial joint affecting multiple joints. In
the past decade, we have witnessed conceptual switch of OA pathogenesis from a 'wear and …

Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip
fracture prediction. Therefore, we investigated whether FNW is related to hip fracture risk …