Transient receptor potential (TRP) channels are a large and diverse family of
transmembrane ion channels that are widely expressed, have important physiological roles …

Cancer patients often experience changes in mental health, prompting an exploration into
whether nerves infiltrating tumors contribute to these alterations by impacting brain …

The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of
dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face …

Corneal nerve impairment contributes significantly to dry eye disease (DED) symptoms and
is thought to be secondary to corneal epithelial damage. Transient receptor potential …

Noxious stimuli activate nociceptive sensory neurons, causing action potential firing and the
release of diverse signaling molecules. Several peptides have already been identified to be …

Localized provoked vulvodynia is characterized by chronic vulvar pain that disrupts every
aspect of the patient's life. Pain is localized to the vulvar vestibule, a specialized ring of …

Tactile and pain perception are essential for biological skin to interact with the external
environment. This complex interplay of sensations allows for the detection of potential …

Ion channels are integral membrane proteins mediating ion flow in response to changes in
their environment. Among the different types of ion channels reported to date, the super …

Caffeine (1, 3, 7-trimethylxanthine) is a naturally occurring methylxanthine that acts as a
potent central nervous system stimulant found in more than 60 different plants and fruits …

Aims Gastrointestinal paresthesia and dysmotility are common side effects of vincristine
(VCR) chemotherapy, which have become one of the factors for dose reduction, therapy …