[HTML][HTML] Physiologically based kinetic (PBK) modeling of propiconazole using a machine learning-enhanced read-across approach for interspecies extrapolation
A significant challenge in the traditional human health risk assessment of agrochemicals is
the uncertainty in quantifying the interspecies differences between animal models and …
the uncertainty in quantifying the interspecies differences between animal models and …
[HTML][HTML] Using Read-Across to build Physiologically-Based Kinetic models: Part 2. Case studies for atenolol and flumioxazin
CV Thompson, SD Webb, JA Leedale… - Computational …, 2024 - Elsevier
Read-across, wherein information from a data-rich chemical is used to make a prediction for
a similar chemical that lacks the relevant data, is increasingly being accepted as an …
a similar chemical that lacks the relevant data, is increasingly being accepted as an …
[HTML][HTML] Using read-across to build physiologically-based kinetic models: Part 1. Development of a KNIME workflow to assist analogue selection for PBK modelling
CV Thompson, SD Webb, JA Leedale… - Computational …, 2024 - Elsevier
Read-across refers to the process by which information from one (source) chemical is used
to infer information about another similar (target) chemical. This method can be used to fill …
to infer information about another similar (target) chemical. This method can be used to fill …
A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis
K Mi, L Sun, L Zhang, A Tang, X Tian, Y Hou… - Frontiers in …, 2024 - frontiersin.org
Introduction: Streptococcus suis (S. suis) is a zoonotic pathogen threatening public health.
Aditoprim (ADP), a novel veterinary medicine, exhibits an antibacterial effect against S. suis …
Aditoprim (ADP), a novel veterinary medicine, exhibits an antibacterial effect against S. suis …