The gastrointestinal tract is an immunologically rich organ, containing complex cell networks
and dense lymphoid structures that safeguard this large absorptive barrier from pathogens …

Inflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition
affecting the gastrointestinal tract, impacting millions of individuals globally. The balance …

Leucine-rich repeat kinase 2 (LRRK2), a Rab kinase associated with Parkinson's disease
and several inflammatory diseases, has been shown to localize to stressed lysosomes and …

By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of
severe asthmatics drives the formation of pathologic mucus which leads to airway mucus …

Gut barrier dysfunction and related inflammation are known to be associated with the
development and progression of colorectal cancer (CRC). We investigated associations of …

Background Many patients with moderately to severely active Crohn's disease do not
respond to available therapies or lose response over time. The GALAXI-1 study previously …

Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the
ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as …

Crohn's disease is a chronic, debilitating, inflammatory bowel disease. Here, we report a
critical role of phospholipase C-β3 (PLC-β3) in intestinal homeostasis. In PLC-β3-deficient …

As a safer and more environmentally friendly alternative to lead-based perovskite, lead-free
tin halide perovskite solar cells (PSCs) have gained significant attention. However, these …