Macrocyclization Strategy for Improving Candidate Profiles in Medicinal Chemistry

O Darlami, R Pun, SH Ahn, SH Kim, D Shin - European Journal of …, 2024 - Elsevier
Macrocycles are defined as cyclic compounds with 12 or more members. In medicinal
chemistry, they are categorized based on their core chemistry into cyclic peptides and …

Inflammation as a driver of hematological malignancies

S Saluja, I Bansal, R Bhardwaj, MS Beg… - Frontiers in …, 2024 - frontiersin.org
Hematopoiesis is a tightly regulated process that produces all adult blood cells and immune
cells from multipotent hematopoietic stem cells (HSCs). HSCs usually remain quiescent, and …

Exploring the Mechanisms of the Huangqin Qingfei Decoction in Pneumonia Treatment for Lipopolysaccharide-Induced Mouse Model: A Network Pharmacology …

Z Zheng, J Lei, J Chang, X Yi… - Natural Product …, 2024 - journals.sagepub.com
Objective: In this study, a network pharmacological approach, and in vivo validation
experiments were used to screen the active components of the Huangqin Qingfei decoction …