[HTML][HTML] Targeting SWI/SNF complexes in cancer: pharmacological approaches and implications
MR Dreier, J Walia, IL de la Serna - Epigenomes, 2024 - mdpi.com
SWI/SNF enzymes are heterogeneous multi-subunit complexes that utilize the energy from
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …
ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and …
Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo [4, 5-c] quinnolin-7-yl)-3, 5-dimethylisoxazole as a potent and selective BET inhibitor for …
S Yu, Y Zhang, J Yang, H Xu, S Lan, B Zhao… - European Journal of …, 2024 - Elsevier
The functions of the bromodomain and extra terminal (BET) family of proteins have been
proved to be involved in various diseases, particularly the acute myeloid leukemia (AML). In …
proved to be involved in various diseases, particularly the acute myeloid leukemia (AML). In …
[HTML][HTML] Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1
R Hu, H Hou, Y Li, M Zhang, X Li, Y Chen, Y Guo… - Theranostics, 2024 - ncbi.nlm.nih.gov
Rationale: The response rate to the MEK inhibitor trametinib in BRAF-mutated melanoma
patients is less than 30%, and drug resistance develops rapidly, but the mechanism is still …
patients is less than 30%, and drug resistance develops rapidly, but the mechanism is still …
[HTML][HTML] Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently
no disease-modifying treatment options available. Mutations in GRN are one of the most …
no disease-modifying treatment options available. Mutations in GRN are one of the most …
[HTML][HTML] BET bromodomain inhibitors PFI-1 and CPI-203 suppress the development of follicular lymphoma via regulating Wnt/β-catenin signaling
M Bai, Y Huang, X Suo, L Wang, W Han, W Zhang - Heliyon, 2024 - cell.com
Objective Follicular lymphoma (FL) is an indolent B-cell lymphoproliferative disorder,
characterized by a lymphoid follicular pattern of growth. PFI-1 or CPI-203 has been known to …
characterized by a lymphoid follicular pattern of growth. PFI-1 or CPI-203 has been known to …
[PDF][PDF] Discovery of Novel Inhibitors of BRD4 Treating Prostate Cancer: A Comprehensive Case Study for Considering Water Network in Virtual Screening and Drug …
H Zhonga, X Wanga, S Chena, Z Wanga, H Wanga… - researchgate.net
Androgen receptor (AR) is the primary target for treating prostate cancer (PCa), which
inevitably progresses due to drug-resistant mutations. Bromodomain-containing protein 4 …
inevitably progresses due to drug-resistant mutations. Bromodomain-containing protein 4 …