In vitro models are essential to a broad range of biomedical research, such as pathological
studies, drug development, and personalized medicine. As a potentially transformative …

Limitations with cell cultures and experimental animal-based studies have had the scientific
and industrial communities searching for new approaches that can provide reliable human …

Engineered human cardiac tissues have been utilized for various biomedical applications,
including drug testing, disease modeling, and regenerative medicine. However, the …

Cardiovascular disease is a major cause of mortality worldwide, and current preclinical
models including traditional animal models and 2D cell culture models have limitations in …

Cardiac microtissues provide a promising platform for disease modeling and developmental
studies, which require the close monitoring of the multimodal excitation-contraction …

Cardiovascular diseases are caused by hereditary factors, environmental conditions, and
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …

Patient‐derived organoids (PDOs) developed ex vivo and in vitro are increasingly used for
therapeutic screening. They provide a more physiologically relevant model for drug …

High-throughput 3D microfluidic cell culture systems can be designed to model aspects of
human tissues and organs and may thus serve as non-clinical evaluation tools. They benefit …

Abstract Organs-on-chips (OoCs) are in vitro models that simulate the anatomical and
physiological structure of human organs at the micro-scale level. With the advantages of …

Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …