Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease

MJ Holtzman, Y Zhang, K Wu… - European Respiratory …, 2024 - Eur Respiratory Soc
Respiratory viral infections are a major public health problem, with much of their morbidity
and mortality due to post-viral lung diseases that progress and persist after the active …

[HTML][HTML] Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke–induced severe flu

TW Kaminski, T Brzoska, X Li, R Vats, O Katoch… - JCI insight, 2024 - ncbi.nlm.nih.gov
Cigarette smoking is associated with a higher risk of ICU admissions among patients with
flu. However, the etiological mechanism by which cigarette smoke (CS) exacerbates flu …

Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD

C Chung, SY Park, JY Huh, NH Kim, CH Shon… - Journal of …, 2024 - Springer
Background Exposure to noxious particles, including cigarette smoke and fine particulate
matter (PM2. 5), is a risk factor for chronic obstructive pulmonary disease (COPD) and …

Persistence of emphysema following cessation of cigarette smoke exposure requires a susceptibility factor

ZH Negasi, N Nommi, C Liu… - American Journal of …, 2024 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is caused by cigarette smoke (CS) exposure
but can often be progressive even in former smokers. Exposure of mice to CS for 22 wk …

[HTML][HTML] 慢性多叶段支气管狭窄阻塞病因机制探讨

崔小丽, 吴明军, 雷丰, 薛庆亮 - Advances in Clinical Medicine, 2024 - hanspub.org
慢性多叶段支气管狭窄阻塞(Chronic multilobar segmental bronchial stenosis or obstruction)
是一种在胸部CT 上具有多个叶段支气管狭窄, 并气管镜下表现为支气管黏膜增生, 肿胀 …

Persistence of Emphysema Following Cessation of Cigarette Smoke 2 Exposure Requires a Susceptibility Factor 3

ZH Negasi, N Nommi, C Liu, Y Tesfaigzi, Y Tesfaigzi - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is caused by cigarette smoke (CS) exposure
28 but can be often progressive even in former smokers. Exposure of mice to CS for 22 …

IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases

G Del Val, E Schiffrin - US Patent 11,926,663, 2024 - Google Patents
The present invention provides means and methods for treating Interleukin 18 (IL-18)-
associated diseases and disorders. In particular, the present invention discloses antibodies …