Sirtuin insights: bridging the gap between cellular processes and therapeutic applications
The greatest challenges that organisms face today are effective responses or detection of
life-threatening environmental changes due to an obvious semblance of stress and …
life-threatening environmental changes due to an obvious semblance of stress and …
Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1-HIF-2α axis
J Suh, H Kim, J Min, HJ Yeon, M Hemberg… - Cell Reports …, 2024 - cell.com
Chondrosarcomas represent the second most common primary bone malignancy. Despite
the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD+) …
the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD+) …
[HTML][HTML] A proteasome-dependent inhibition of SIRT-1 by the resveratrol analogue 4, 4′-dihydroxy-trans-stilbene
V Livraghi, L Mazza, F Chiappori, M Cardano… - Journal of Traditional …, 2024 - Elsevier
Background and aim Resveratrol (RSV), is a stilbene-based compound exerting wide
biological properties. Its analogue 4, 4′-dihydroxy-trans-stilbene (DHS) has shown …
biological properties. Its analogue 4, 4′-dihydroxy-trans-stilbene (DHS) has shown …
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury
LS Wijaya, A Gabor, IE Pot, L van de Have… - Toxicological …, 2024 - academic.oup.com
Drug-induced liver injury (DILI) remains the main reason for drug development attritions
largely due to poor mechanistic understanding. Toxicogenomic to interrogate the …
largely due to poor mechanistic understanding. Toxicogenomic to interrogate the …
Potential anti-liver cancer targets and mechanisms of kaempferitrin based on network pharmacology, molecular docking and experimental verification
S Zhou, H Zhang, J Li, W Li, M Su, Y Ren, F Ge… - Computers in Biology …, 2024 - Elsevier
Aim Kaempferitrin is an active component in Chenopodium ambrosioides, showing
medicinal functions against liver cancer. This study aimed to identify the potential targets …
medicinal functions against liver cancer. This study aimed to identify the potential targets …
Jiawei Dachaihu decoction protects against mitochondrial dysfunction in atherosclerosis (AS) mice with chronic unpredictable mild stress (CUMS) via SIRT1/PGC-1α …
H Shi, M Sun, S Wang, F He, R Yang, Z Li… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance JiaWei DaChaiHu is composed of Bupleurum
chinense, Scutellaria baicalensis, Pinellia ternata, Paeonia lactiflora, Zingiber officinale …
chinense, Scutellaria baicalensis, Pinellia ternata, Paeonia lactiflora, Zingiber officinale …
Sirtuin 1 regulates the phenotype and functions of dendritic cells through Ido1 pathway in obesity.
Abstract Sirtuin 1 (SIRT1) is a class III histone deacetylase (HDAC3) that plays a crucial role
in regulating the activation and differentiation of dendritic cells (DCs) as well as controlling …
in regulating the activation and differentiation of dendritic cells (DCs) as well as controlling …