In males but not in females, brain derived neurotrophic factor (BDNF) plays an obligatory
role in the onset and maintenance of neuropathic pain. Afferent terminals of injured …

Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and
Drug Administration (FDA), have found successful application in clinical practice. They hold …

Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …

Pain is the most debilitating symptom of knee osteoarthritis (OA) that can even persist after
total knee replacement. The severity and duration of pain do not correlate well with joint …

Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …

Neuropathic pain is a severe and chronic condition widely found in the general population.
The reason for this is the extensive variety of damage or diseases that can spark this …

Despite the recognized importance of the spinal cord in sensory processing, motor
behaviors, and neural diseases, the underlying organization of neuronal clusters and their …

Macrophages and satellite glial cells are found between injured and uninjured neurons in
the lumbar dorsal root ganglia (DRG). We explored the mechanism of neuro‐immune and …

Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …

Microbial transformation of per-and polyfluoroalkyl substances (PFAS), including
fluorotelomer-derived PFAS, by native microbial communities in the environment has been …